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ting that this malarial parasite was the first to be cultured in vitro be- So, this is where we stand. What follows is the original Plasmodium cause it was also the first human malarial parasite life cycle to be re- falciparum in vitro culture paper published in Science and written by solved by Grassi in the late 19th century. Moreover, it is still the most William Trager and James Jensen. It contains a full description of their lethal of the 4 primary species infecting humans in the world. outstanding contribution to the fields of malariology and parasitology. When Dick Seed informed one of us (G.W.E.) regarding Professor We decided to run Jensen’s contribution as a part of our ‘‘Defining the Trager’s passing, I remarked that we needed to find someone who would Field’’ series because their publication did so much for our basic un- write an In Memoriam. Just a few days later, I received an e-mail from derstanding of malaria and because their discovery laid the groundwork for so much of what was to follow during the next 29 yr. Then comes James Jensen, the coauthor of the paper in Science in which he and the paper by James Jensen, who describes for us some of the ‘‘high and Trager published the details of their breakthrough discovery (Trager, W., low spots’’ that occurred during their seminal research efforts. We think and J. B. Jensen. 1976. Human malaria parasites in continuous culture. the dual presentations will give us a realistic appreciation of their efforts Science 193: 673–675). In his note, Jensen volunteered to write a paper and success. for the Journal of Parasitology in which he would describe some of the trials and tribulations he and Trager had suffered through, as well as the triumph of discovery he and Trager achieved with their research Gerald W. Esch, Department of Biology, Wake Forest University, Win- to develop the new culture technique. I immediately said ‘‘yes.’’ ston-Salem, North Carolina 27109; John A. Oaks, Department of Com- Then, we began to think that it would be a nice thing if we could parative Biosciences, School of Veterinary Medicine, University of Wis- consin, Madison, Wisconsin 53706. persuade AAAS to give us permission to reproduce the paper and pub-
The Journal of Parasitology – Allen Press
Published: Jun 1, 2005
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