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Post‐transplantation cardiac xenograft growth in an orthotopic pig to baboon model is a life‐limiting phenomenon that is poorly understood. Possible causes of growth include both intrinsic and extrinsic etiologies. Extrinsic causes are thought to be attributed to maladaptive hypertrophy as a...
Islet transplantation is a potential treatment option for certain patients with type 1 diabetes; however, it still faces barriers to widespread use, including the lack of tools to monitor islet grafts post‐transplantation. This study investigates whether labeling neonatal porcine islets (NPI)...
Three excellent presentations at an industry‐sponsored symposium at the (virtual) congress of the combined IXA/CTRMS (September 23–25, 2021) were directed to the value and limitations of the pig‐to‐nonhuman primate (NHP) kidney transplantation model. Daniel Firl and James Markmann provided a...
The initial clinical trials of pig solid organ xenotransplantation (XTx) are drawing closer and could begin in the coming years. The first clinical trials may aim to transplant genetically‐modified pig kidneys into adult humans. The impetus for beginning these first‐in‐human trials is the severe...
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