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The activation of the endothelial surface in xenografts is still a poorly understood process and the consequences are unpredictable. The role of Ca2+‐messaging during the activation of endothelial cells is well recognized and routinely measured by synthetic Ca2+‐sensitive fluorophors. However,...
Xenotransplantation may be an alternative source of organs for patients with end‐stage organ failure, but problems remain to be overcome. Five factors that are problematic are (a) a sustained systemic inflammatory response in the xenograft recipient, (b) thrombotic microangiopathy and...
The use of decellularized xenogeneic heart valves might offer a solution to overcome the issue of human valve shortage. The aim of this study was to revise decellularization protocols in combination with enzymatic deglycosylation, in order to reduce the immunogenicity of porcine pulmonary heart...
Genetically engineered pigs are now available for xenotransplantation in which all three known carbohydrate xenoantigens, against which humans have natural antibodies, have been deleted (triple‐knockout [TKO] pigs). Furthermore, multiple human transgenes have been expressed in the TKO pigs, all...
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