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Background Anti‐Gal is the most abundant natural antibody in humans and Old World primates (apes and Old World monkeys). Its ligand, the α‐gal epitope (Galα1‐3Galβ1‐4GlcNAc‐R), is abundant in nonprimate mammals, prosimians and New World monkeys whereas it is absent in humans and Old World...
Background The temporary or long‐term xenotransplantation of pig organs into people would save thousands of lives each year if not for the robust human antibody response to pig carbohydrates. Genetically engineered pigs deficient in galactose α1,3 galactose (gene modified: GGTA1) and...
The histopathology of cardiac xenograft rejection has evolved over the last 20 yr with the development of new modalities for limiting antibody‐mediated injury, advancing regimens for immune suppression, and an ever‐widening variety of new donor genetics. These new technologies have helped us...
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