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Beta cell replacement therapy represents the only way towards complete restoration of the physiological glucose homeostasis in patients with Type 1 diabetes. Xenotransplantation of transgenic pig islets expressing immunomodulatory molecules might represent a promising approach to overcome the...
In April this year, the final year of our German Xenotransplantation Research Group began, a consortium of animal biotechnologists, immunologists, virologists and clinical transplantat specialists. Many advances included • new molecular insights in xenogeneic responses (Thrombomodulin, HLA‐E,...
The model of porcine islet cell transplant to the diabetic macaque is well accepted to study efficacy in and immunological interference. This life‐supporting model is therefore considered an integral component in translational research, i.e. in efficacy‐toxicity studies before the phase...
Scalea J, Hanecamp I, Robson SC, Yamada K. T‐cell‐mediated immunological barriers to xenotransplantation. Xenotransplantation 2012; 19: 23–30. © 2012 John Wiley & Sons A/S. Abstract: Xenotransplantion remains the most viable option for significant expansion of the donor organ pool in clinical...
Regulatory CD4+CD25+Foxp3+ T cells (Tregs) play an important role in the induction of allospecific tolerance. However tolerance in solid organ transplantation by mere transfer of Tregs has been difficult. Besides this the stability of the differentiation phenotype of Tregs has recently been...
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