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Abstract: Background: Multi‐transgenic pigs produced for use in xenotransplantation have to be screened for the presence and expression of porcine endogenous retroviruses (PERV) to select animals with low PERV load. The production of transgenic pigs may also be associated with the integration of...
Abstract: Background: To investigate the role of T cells and natural killer (NK) cells in mediating corneal xenograft rejection in a pig‐to‐mouse model. Methods: Pig corneas were orthotopically transplanted into BALB/c, C57BL/6, nude, severe combined immunodeficiency (SCID), and NOD/SCID/γcnull...
Abstract: Background: The microcirculation was assessed in the livers of human decay accelerating factors (hDAF) and wild‐type transgenic rats by fluorescent intravital microscopy, histology and histomorphology to determine the benefits of hDAF expression for the microcirculation of a rat liver...
Abstract: Background: We previously demonstrated the ability of a human isolate of coxsackievirus‐B5 (CVB5) to infect productively adult porcine islet cells (PICs) in vitro. PICs infected with CVB5 remain viable, and upon transplantation reversed diabetes in C56BL/6 mice for up to 5 days....
Abstract: Background: Carbon monoxide (CO) interferes with inflammatory and apoptotic processes associated with ischemia–reperfusion injury and graft rejection. Here, the in vitro effects of carbon monoxide releasing molecule‐3 (CORM‐3), a novel water‐soluble carbonyl CO carrier, have been...
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