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Abstract: Background: Pigs are currently considered the most likely source of organs for human xenotransplantation because of anatomical and physiological similarities to humans, and the relative ease to be bred in large numbers. Along with the fast development of the genetic engineering and...
Abstract: Background: Islet cell transplantation is a novel therapeutic modality for the cure of diabetes. Pig islet cells are an attractive substitute for human islet cells; however, they are known to be particularly difficult to isolate because of a weak islet capsule and a tendency to be...
Abstract: Background: Human natural killer (NK) cell‐mediated cytotoxicity represents a hurdle in pig‐to‐human xenotransplantation. It was previously reported that the expression of human major histocompatibility complex class I molecules, including HLA‐B27, ‐Cw3, ‐E, and ‐G, partially protects...
Abstract: Background: Previous studies showed that α‐1,2‐fucosyltransferase (HT), decay accelerating factor (DAF), and CD59 have an inhibitory effect on the immunological rejection of xenogenic transplantation. Methods: To investigate their possible synergistic effects in suppression of...
Abstract: Background: Porcine endogenous retroviruses (PERVs) released from pig tissue can infect selected human cells in vitro and therefore represent a safety risk for xenotransplantation using pig cells, tissues, or organs. Although PERVs infect cells of numerous species in vitro, attempts to...
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