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Abstract: The endothelium, as an organ at the interface between the intra‐ and extravascular space, actively participates in maintaining an anti‐inflammatory and anti‐coagulant environment under physiological conditions. Severe humoral as well as cellular rejection responses, which accompany...
Abstract: Xenotransplantation using porcine organs may resolve a chronic shortage of donor organs for clinical transplantation if significant immunological barriers can be overcome. To determine the potential role of T lymphocytes in Xenograft (Xg) rejection, we transplanted transgenic hCD46...
Abstract: Background: Xenotransplanted patients produce xenospecific IgG1 antibodies directed against epitopes other than Galα1,3Gal. IgG1 antibody production is believed to be dependent upon T cell help. Therefore, as a natural continuation of our work aimed at characterizing the xenoimmune...
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