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Abstract: The first and major clinical obstacle in xenotransplantation is antibody‐mediated hyperacute rejection. Although human natural antibodies against Galα1,3Gal (Gal) antigens, which are common on porcine cells and organs, have been identified to play a major role in hyperacute rejection,...
Fox A, Mountford J, Braakhuis A, Harrison LC. High avidity antibodies to fetal pig pancreas endocrine cells transfer rejection but are not normally generated to fetal pig pancreas xenografts. Xenotransplantation 2002; 9: 382–392. © Blackwell Munksgaard, 2002 Previous studies on the contribution...
Olack BJ, Jaramillo A, Benshoff ND, Kaleem Z, Swanson CJ, Lowell JA, Mohanakumar T. Rejection of porcine islet xenografts mediated by CD4+ T cells activated through the indirect antigen recognition pathway. Xenotransplantation 2002; 9: 393–401. © Blackwell Munksgaard, 2002 We have previously...
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