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1,3-Dimethyl-6-trifluoromethanesulfonyloxylumazine is prepared by a reaction of 1,3-dimethyllumazine 5-oxide with trifluoromethanesulfonic anhydride and is converted efficiently into lumazines with various substituents, for example amino, halogens, phenylthio, thiocyano, phenylseleno, and so on,...
We examined the inhibitory effect of tetrahydrobiopterin (BPH 4 ) on L-β-(3,4-dihydroxyphenyl)alanine (DOPA)-induced cytotoxicity in PC-12 cells. First in vitro inhibitory efficacy of BPH4 on lipid peroxidation induced by Fe 3+ -DOPA complex was confirmed by using PC-liposomes. Fe 3+ -DOPA...
In 20 women after abdominal hysterectomy, a statistically significant increase of neopterin was observed. Because large amounts of neopterin are produced by macrophages upon stimulation with interferon-γ the data demonstrate significant cell -mediated immune activation in patients after surgery....
The effects of 17 different pteridine derivatives on rat liver microsomal cytochrome P-450 catalyzed degradation of aminoantipyrin were studied. Neopterin (41% of control), biopterin (42%), monapterin (73%), pterin (74%), lumazine (75%) and 6-methylpterin (77%) significantly inhibit the...
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