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Summary Reduction of 1.3-dimethyllumazine (1) by zinc dust in Ac 2 O/AcOH leads to the formation of 6-7 connected bis-Iumazinyl derivatives. Depending on the reaction conditions either 7 -(5-acetyl-5,6, 7,8-tetrahydro-1.3-dimethyllumazin- 6-yl)-l, 3-dimethyllumazin (3) or isomeric 7...
Summary To facilitate the rather labour consuming synthesis of antifolate γ-oligo-L-glutamates including those with the propargyl group at position N 10 , two synthons possessing this group, α-t-butyl γ-methyl N-(4-propargylaminobenzoyl)- L-glutamate (1) and a-t-butyl...
Summary An elevation of serum angiotensin-converting enzyme (ACE) has been reported in some disorders associated with immune activation, e.g. sarcoidosis, HIV infection or ulcerative colitis. Both endothelial cells and macrophages are thought to be the possible source of increased ACE levels. We...
Summary Immune stimulation due to secondary infection may enhance HIV replication and viraemia, since cellular activation of CD4+T-cells is required for viral replication. We describe a case of an 18 months old child, exposed intrauterinely to human immunodeficiency virus type 1 (HIV -1). During...
Summary A statistical reinvestigation was performed on data from two separate earlier studies, investigating heatshock protein 65 and neopterin in the same population of subjects examined for the presence of carotid atherosclerosis. Both heat-shock protein 65 and neopterin concentrations are...
Summary In 62 patients diagnosed as sporadic amyotrophic lateral sclerosis (sALS), we quantitated serum concentrations of neopterin, β 2 -microglobulin. kynurenine and tryptophan. A linear increase with age was demonstrated by neopterin more than by β 2 -microglobulin, whereas neither parameter...
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