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Pharmacogenetics and Genomics

Subject Areas: Genetics; ; ; ; ; ;
Publisher: Wolters Kluwer - Wolters Kluwer Health
ISSN: 1744-6880
SJR: 144

LitStream

Journal Article

Pharmacogenetic considerations in therapy with novel antiplatelet and anticoagulant agents

Yazbeck, Anthony; Akika, Reem; Awada, Zainab; Zgheib, Nathalie K.

2024 Pharmacogenetics and Genomics

doi:10.1097/fpc.0000000000000520 pmid:38372412

Antiplatelets and anticoagulants are extensively used in cardiovascular medicine for the prevention and treatment of thrombosis in the venous and arterial circulations. Wide inter-individual variability has been observed in response to antiplatelets and anticoagulants, which triggered...
LitStream

Journal Article

Pharmacogenetics at scale in real-world bioresources: CYP2C19 and clopidogrel outcomes in UK Biobank

Bedair, Khaled F.; Smith, Blair; Palmer, Colin N.A.; Doney, Alex S.F.; Pearson, Ewan R.

2024 Pharmacogenetics and Genomics

doi:10.1097/fpc.0000000000000519 pmid:38179710

Objective The impact of CYP2C19 genotype on clopidogrel outcomes is one of the most well established pharmacogenetic interactions, supported by robust evidence and recommended by the Food and Drug Administration and clinical pharmacogenetics implementation consortium. However, there is a...
LitStream

Journal Article

Common dihydropyrimidinase (DPYS) genetic variations do not predict fluoropyrimidine-related chemotherapy toxicity in a Canadian cohort

Medwid, Samantha J.; Mailloux, Jaymie L.; Wigle, Theodore J.; Kim, Richard B.

2024 Pharmacogenetics and Genomics

doi:10.1097/fpc.0000000000000521 pmid:38215018

Known genetic variations in dihydropyrimidine dehydrogenase (gene name DPYD) do not fully predict patients at risk for severe fluoropyrimidine-associated chemotherapy toxicity. Dihydropyrimidinase (gene name DPYS), the second catabolic enzyme in fluoropyrimidine metabolism, has been noted as a...
LitStream

Journal Article

Pharmacogenomics and major depressive disorder: time to take a stance?

Boivin, Nicholas R.; Jusufi, Herolind

2024 Pharmacogenetics and Genomics

doi:10.1097/fpc.0000000000000518 pmid:38179699

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