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npj Vaccines Volume 7 Issue 1

Subject Areas: Immunology; ; ; ; ;
Publisher: Nature Publishing Group UK - Springer Journals
SJR: 30

Open Access

Journal Article

Predicted effectiveness of vaccines and extended half-life monoclonal antibodies against RSV hospitalizations in children

Zheng, Zhe; Weinberger, Daniel M.; Pitzer, Virginia E.

2022 npj Vaccines

doi:10.1038/s41541-022-00550-5 pmid:36302926

Several vaccines and extended half-life monoclonal antibodies (mAbs) against respiratory syncytial virus (RSV) have shown promise in clinical trials. We used age-structured transmission models to predict the possible impact of various RSV prevention strategies including maternal immunization,...
Open Access

Journal Article

Development of antibody-dependent cellular cytotoxicity in response to recombinant and live-attenuated herpes zoster vaccines

Park, Seong Yeon; Levin, Myron J.; Canniff, Jennifer; Johnson, Michael; Schmid, D. Scott; Weinberg, Adriana

2022 npj Vaccines

doi:10.1038/s41541-022-00545-2 pmid:36284110

Zoster vaccines generate antibody responses against varicella-zoster virus (VZV). We compared antibody-dependent cell cytotoxicity (ADCC) elicited by zoster vaccine live (ZVL) and recombinant zoster vaccine (RZV). ADCC mediated by antibodies against VZV lysate (VZV-ADCC) and recombinant...
Open Access

Journal Article

Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination

Miyashita, Yusuke; Yoshida, Takanobu; Takagi, Yuriko; Tsukamoto, Hirotake; Takashima, Ken; Kouwaki, Takahisa; Makino, Katsunari; Fukushima, Satoshi; Nakamura, Kimitoshi; Oshiumi, Hiroyuki

2022 npj Vaccines

doi:10.1038/s41541-022-00439-3 pmid:35136071

mRNA-based vaccines have been used globally to eradicate the coronavirus-disease 2019 (COVID-19) pandemic. Vaccine efficacy and adverse reactions depend on immune responses, such as proinflammatory cytokine production and lymphocyte activation. We conducted a prospective cohort study to...
Open Access

Journal Article

Anti-Ad26 humoral immunity does not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination

Byazrova, Maria G.; Astakhova, Ekaterina A.; Minnegalieva, Aygul R.; Sukhova, Maria M.; Mikhailov, Artem A.; Prilipov, Alexey G.; Gorchakov, Andrey A.; Filatov, Alexander V.

2022 npj Vaccines

doi:10.1038/s41541-022-00566-x pmid:36379998

Replication-incompetent adenoviral vectors have been extensively used as a platform for vaccine design, with at least four anti-COVID-19 vaccines authorized to date. These vaccines elicit neutralizing antibody responses directed against SARS-CoV-2 Spike protein and confer significant level of...
Open Access

Journal Article

Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy

Brumme, Zabrina L.; Mwimanzi, Francis; Lapointe, Hope R.; Cheung, Peter K.; Sang, Yurou; Duncan, Maggie C.; Yaseen, Fatima; Agafitei, Olga; Ennis, Siobhan; Ng, Kurtis; Basra, Simran; Lim, Li Yi; Kalikawe, Rebecca; Speckmaier, Sarah; Moran-Garcia, Nadia; Young, Landon; Ali, Hesham; Ganase, Bruce; Umviligihozo, Gisele; Omondi, F. Harrison; Atkinson, Kieran; Sudderuddin, Hanwei; Toy, Junine; Sereda, Paul; Burns, Laura; Costiniuk, Cecilia T.; Cooper, Curtis; Anis, Aslam H.; Leung, Victor; Holmes, Daniel; DeMarco, Mari L.; Simons, Janet; Hedgcock, Malcolm; Romney, Marc G.; Barrios, Rolando; Guillemi, Silvia; Brumme, Chanson J.; Pantophlet, Ralph; Montaner, Julio S. G.; Niikura, Masahiro; Harris, Marianne; Hull, Mark; Brockman, Mark A.

2022 npj Vaccines

doi:10.1038/s41541-022-00452-6 pmid:35228535

Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain incompletely characterized. We measured circulating antibodies against the SARS-CoV-2 spike protein receptor-binding domain (RBD), ACE2 displacement and viral neutralization activities one month following the first and...
Open Access

Journal Article

Challenges and developments in universal vaccine design against SARS-CoV-2 variants

Zhao, Fangxin; Zai, Xiaodong; Zhang, Zhiling; Xu, Junjie; Chen, Wei

2022 npj Vaccines

doi:10.1038/s41541-022-00597-4 pmid:36535982

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had become a global concern because of its unexpectedly high pathogenicity and transmissibility. SARS-CoV-2 variants that reduce the immune protection elicited from previous vaccination or natural infection raise...
Open Access

Journal Article

Versatility of live-attenuated measles viruses as platform technology for recombinant vaccines

Ebenig, Aileen; Lange, Mona V.; Mühlebach, Michael D.

2022 npj Vaccines

doi:10.1038/s41541-022-00543-4 pmid:36243743

Live-attenuated measles virus (MeV) has been extraordinarily effective in preventing measles infections and their often deadly sequelae, accompanied by remarkable safety and stability since their first licensing in 1963. The advent of recombinant DNA technologies, combined with systems to...
Open Access

Journal Article

Rapid generation of Shigella flexneri GMMA displaying natural or new and cross-reactive O-Antigens

Gasperini, Gianmarco; Raso, Maria Michelina; Schiavo, Fabiola; Aruta, Maria Grazia; Ravenscroft, Neil; Bellich, Barbara; Cescutti, Paola; Necchi, Francesca; Rappuoli, Rino; Micoli, Francesca

2022 npj Vaccines

doi:10.1038/s41541-022-00497-7 pmid:35773292

Generalized modules for membrane antigens (GMMA) are exosomes released from engineered Gram-negative bacteria and represent an attractive vaccine platform for the delivery of the O-Antigen (OAg), recognized as the key target for protective immunity against several pathogens such as Shigella....
Open Access

Journal Article

An adjuvanted subunit SARS-CoV-2 spike protein vaccine provides protection against Covid-19 infection and transmission

Tabynov, Kairat; Turebekov, Nurkeldi; Babayeva, Meruert; Fomin, Gleb; Yerubayev, Toktassyn; Yespolov, Tlektes; Li, Lei; Renukaradhya, Gourapura J.; Petrovsky, Nikolai; Tabynov, Kaissar

2022 npj Vaccines

doi:10.1038/s41541-022-00450-8 pmid:35197485

Recombinant protein approaches offer major promise for safe and effective vaccine prevention of SARS-CoV-2 infection. We developed a recombinant spike protein vaccine (called NARUVAX-C19) and characterized its ability when formulated with a nanoemulsion adjuvant to induce anti-spike antibody and...
Open Access

Journal Article

Assembly-defective Tembusu virus ectopically expressing capsid protein is an approach for live-attenuated flavivirus vaccine development

He, Yu; Guo, Jiaqi; Wang, Xiaoli; Zhang, Senzhao; Mao, Li; Hu, Tao; Wang, Mingshu; Jia, Renyong; Zhu, Dekang; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, Shaqiu; Huang, Juan; Mao, Sai; Ou, Xumin; Gao, Qun; Sun, Di; Cheng, Anchun; Chen, Shun

2022 npj Vaccines

doi:10.1038/s41541-022-00468-y pmid:35550523

Live-attenuated vaccines (LAVs) represent a promising approach for flavivirus vaccine development. In the present study, we demonstrated a method for generating flavivirus LAVs based on breaking spatially and temporally regulated C-prM cleavage to disturb the viral assembly process, using an...

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