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npj Regenerative Medicine

Subject Areas: Cell Biology; ; ; ; ;
Publisher: Nature Publishing Group UK - Springer Journals
SJR: 22

Open Access

Journal Article

Intrinsic and extrinsic actions of human neural progenitors with SUFU inhibition promote tissue repair and functional recovery from severe spinal cord injury

Chen, Yong-Long; Feng, Xiang-Lan; Tam, Kin-Wai; Fan, Chao-Yang; Cheung, May Pui-Lai; Yang, Yong-Ting; Wong, Stanley; Shum, Daisy Kwok-Yan; Chan, Ying-Shing; Cheung, Chi-Wai; Cheung, Martin; Liu, Jessica Aijia

2024 npj Regenerative Medicine

doi:10.1038/s41536-024-00352-4 pmid:38519518

Neural progenitor cells (NPCs) derived from human pluripotent stem cells(hPSCs) provide major cell sources for repairing damaged neural circuitry and enabling axonal regeneration after spinal cord injury (SCI). However, the injury niche and inadequate intrinsic factors in the adult spinal cord...
Open Access

Journal Article

Denervation alters the secretome of myofibers and thereby affects muscle stem cell lineage progression and functionality

Henze, Henriette; Hüttner, Sören S.; Koch, Philipp; Schüler, Svenja C.; Groth, Marco; von Eyss, Björn; von Maltzahn, Julia

2024 npj Regenerative Medicine

doi:10.1038/s41536-024-00353-3 pmid:38424446

Skeletal muscle function crucially depends on innervation while repair of skeletal muscle relies on resident muscle stem cells (MuSCs). However, it is poorly understood how innervation affects MuSC properties and thereby regeneration of skeletal muscle. Here, we report that loss of innervation...
Open Access

Journal Article

A two-way street – cellular metabolism and myofibroblast contraction

Noom, Anne; Sawitzki, Birgit; Knaus, Petra; Duda, Georg N.

2024 npj Regenerative Medicine

doi:10.1038/s41536-024-00359-x pmid:38570493

Tissue fibrosis is characterised by the high-energy consumption associated with myofibroblast contraction. Although myofibroblast contraction relies on ATP production, the role of cellular metabolism in myofibroblast contraction has not yet been elucidated. Studies have so far only focused on...
Open Access

Journal Article

Biological study of skin wound treated with Alginate/Carboxymethyl cellulose/chorion membrane, diopside nanoparticles, and Botox A

Mahheidari, Naimeh; Kamalabadi-Farahani, Mohammad; Nourani, Mohammad Reza; Atashi, Amir; Alizadeh, Morteza; Aldaghi, Niloofar; Salehi, Majid

2024 npj Regenerative Medicine

doi:10.1038/s41536-024-00354-2 pmid:38413625

A hydrogel-based wound dressing with desirable properties is necessary for achieving functional skin integrity post-injury. This study focuses on preparing a hydrogel using Alginate/Carboxymethyl cellulose (Alg/CMC) as a base material. To evaluate its regenerative effects on full-thickness...
Open Access

Journal Article

The adult environment promotes the transcriptional maturation of human iPSC-derived muscle grafts

Crist, Sarah B.; Azzag, Karim; Kiley, James; Coleman, Ilsa; Magli, Alessandro; Perlingeiro, Rita C. R.

2024 npj Regenerative Medicine

doi:10.1038/s41536-024-00360-4 pmid:38575647

Pluripotent stem cell (PSC)-based cell therapy is an attractive option for the treatment of multiple human disorders, including muscular dystrophies. While in vitro differentiating PSCs can generate large numbers of human lineage-specific tissue, multiple studies evidenced that these cell...
Open Access

Journal Article

Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment

Chu, Hongshang; Zhang, Shaoyang; Zhang, Zhenlin; Yue, Hua; Liu, Huijuan; Li, Baojie; Yin, Feng

2024 npj Regenerative Medicine

doi:10.1038/s41536-024-00358-y pmid:38561335

Osteoarthritis affects 15% of people over 65 years of age. It is characterized by articular cartilage degradation and inflammation, leading to joint pain and disability. Osteoarthritis is incurable and the patients may eventually need joint replacement. An emerging treatment is mesenchymal...
Open Access

Journal Article

Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI

Nekanti, Usha; Sakthivel, Pooja S.; Zahedi, Atena; Creasman, Dana A.; Nishi, Rebecca A.; Dumont, Courtney M.; Piltti, Katja M.; Guardamondo, Glenn L.; Hernandez, Norbert; Chen, Xingyuan; Song, Hui; Lin, Xiaoxiao; Martinez, Joshua; On, Lillian; Lakatos, Anita; Pawar, Kiran; David, Brian T.; Guo, Zhiling; Seidlits, Stephanie K.; Xu, Xiangmin; Shea, Lonnie D.; Cummings, Brian J.; Anderson, Aileen J.

2024 npj Regenerative Medicine

doi:10.1038/s41536-024-00356-0 pmid:38499577

Regeneration in the injured spinal cord is limited by physical and chemical barriers. Acute implantation of a multichannel poly(lactide-co-glycolide) (PLG) bridge mechanically stabilizes the injury, modulates inflammation, and provides a permissive environment for rapid cellularization and robust...
Open Access

Journal Article

Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas

Simoliunas, Egidijus; Ruedas-Torres, Inés; Jiménez-Gómez, Yolanda; Edin, Elle; Aghajanzadeh-Kiyaseh, Mozhgan; Zamani-Roudbaraki, Mostafa; Asoklis, Rimvydas; Alksne, Milda; Thathapudi, Neethi C.; Poudel, Bijay K.; Rinkunaite, Ieva; Asoklis, Kasparas; Iesmantaite, Monika; Ortega-Llamas, Laura; Makselis, Almantas; Munoz, Marcelo; Baltriukiene, Daiva; Bukelskiene, Virginija; Gómez-Laguna, Jaime; González-Andrades, Miguel; Griffith, May

2024 npj Regenerative Medicine

doi:10.1038/s41536-024-00355-1 pmid:38429307

Pathophysiologic inflammation, e.g., from HSV-1 viral infection, can cause tissue destruction resulting in ulceration, perforation, and ultimately blindness. We developed an injectable Cornea-in-a-Syringe (CIS) sealant-filler to treat damaged corneas. CIS comprises linear carboxylated polymers of...

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