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Nature Immunology Volume 17 Issue 3

Subject Areas: Immunology; ;
Publisher: Nature Publishing Group US - Springer Journals
ISSN: 1529-2908
SJR: 403

LitStream

Journal Article

The tumor suppressor PTEN has a critical role in antiviral innate immunity

Li, Shun; Zhu, Mingzhu; Pan, Ruangang; Fang, Ting; Cao, Yuan-Yuan; Chen, Shuliang; Zhao, Xiaolu; Lei, Cao-Qi; Guo, Lin; Chen, Yu; Li, Chun-Mei; Jokitalo, Eija; Yin, Yuxin; Shu, Hong-Bing; Guo, Deyin

2015 Nature Immunology

doi:10.1038/ni.3311 pmid:26692175

PTEN functions as a tumor suppressor. Guo and colleagues now find PTEN also serves a critical role in antiviral innate immunity by inducing the production of type I interferon.
LitStream

Journal Article

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Shi, Hexin; Wang, Ying; Li, Xiaohong; Zhan, Xiaoming; Tang, Miao; Fina, Maggy; Su, Lijing; Pratt, David; Bu, Chun Hui; Hildebrand, Sara; Lyon, Stephen; Scott, Lindsay; Quan, Jiexia; Sun, Qihua; Russell, Jamie; Arnett, Stephanie; Jurek, Peter; Chen, Ding; Kravchenko, Vladimir V; Mathison, John C; Moresco, Eva Marie Y; Monson, Nancy L; Ulevitch, Richard J; Beutler, Bruce

2015 Nature Immunology

doi:10.1038/ni.3333 pmid:26642356

NEK7 is a serine-threonine kinase linked to mitosis. Beutler and colleagues show that NEK7 is required for assembly of the NLRP3 inflammasome and restricts NLRP3 activation to interphase of the cell cycle.
LitStream

Journal Article

A septin requirement differentiates autonomous and contact-facilitated T cell proliferation

Mujal, Adriana M; Gilden, Julia K; Gérard, Audrey; Kinoshita, Makoto; Krummel, Matthew F

2015 Nature Immunology

doi:10.1038/ni.3330 pmid:26692174

T cells proliferate in response to cues provided by antigen-presenting cells or high concentrations of cytokines. Krummel and colleagues reveal a distinct requirement for the cytoskeletal protein septin 7 for cytokine-driven bystander T cell proliferation.

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