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The major function of the lysosome is to degrade unwanted materials such as lipids, proteins, and nucleic acids; therefore, deficits of the lysosomal system can result in improper degradation and trafficking of these biomolecules. Diseases associated with lysosomal failure can be lethal and are...
Genome-scale metabolic models (GEMs) have enabled researchers to perform systems-level studies of living organisms. Flux balance analysis (FBA), as a constraint-based technique, enables computation of reaction fluxes and prediction of the metabolic phenotypes of a cell under a set of specified...
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that occurs with the increase of CAG trinucleotide repeats in the huntingtin gene. To understand the mechanisms of HD, powerful proteomics techniques, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
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