DeepDyve requires Javascript to function. Please enable Javascript on your browser to continue.

Leukemia

Subject Areas: Cancer Research; ; ; ;
Publisher: Nature Publishing Group UK - Springer Journals
ISSN: 0887-6924
SJR: 202

Open Access

Journal Article

Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression

Matsui, Shinichiro; Ri, Chihiro; Bolanos, Lyndsey C.; Choi, Kwangmin; Shibamiya, Asuka; Ishii, Arata; Takaishi, Koji; Oshima-Hasegawa, Nagisa; Tsukamoto, Shokichi; Takeda, Yusuke; Mimura, Naoya; Yoshimi, Akihide; Yokote, Koutaro; Starczynowski, Daniel T.; Sakaida, Emiko; Muto, Tomoya

2024 Leukemia

doi:10.1038/s41375-024-02245-3 pmid:38609495

TNF receptor associated factor 6 (TRAF6) is an E3 ubiquitin ligase that has been implicated in myeloid malignancies. Although altered TRAF6 expression is observed in human acute myeloid leukemia (AML), its role in the AML pathogenesis remains elusive. In this study, we showed that the loss of...
Open Access

Journal Article

Prophylactic donor-derived CD19 CAR-T cell infusion for preventing relapse in high-risk B-ALL after allogeneic hematopoietic stem cell transplantation

Lu, Wenyi; Lyu, Hairong; Xiao, Xia; Bai, Xue; Zhang, Meng; Wang, Jiaxi; Pu, Yedi; Meng, Juanxia; Zhang, Xiaomei; Zhu, Haibo; Yuan, Ting; Wang, Bing; Jin, Xin; Cao, Xinping; Wang, Zhao; Xie, Tianle; Meng, Haotian; Stepanov, Alexey V.; Gabibov, Alexander G.; An, Yuxin; Sun, Rui; Zhang, Yu; Maschan, Mikhail A.; Zhu, Zunmin; Zhang, Hongkai; Zhao, Mingfeng

2024 Leukemia

doi:10.1038/s41375-024-02251-5
Open Access

Journal Article

Genome-wide DNA methylation-analysis of blastic plasmacytoid dendritic cell neoplasm identifies distinct molecular features

Künstner, Axel; Schwarting, Julian; Witte, Hanno M.; Xing, Pengwei; Bernard, Veronica; Stölting, Stephanie; Lohneis, Philipp; Janke, Florian; Salehi, Maede; Chen, Xingqi; Kusch, Kathrin; Sültmann, Holger; Chteinberg, Emil; Fischer, Anja; Siebert, Reiner; von Bubnoff, Nikolas; Merz, Hartmut; Busch, Hauke; Feller, Alfred C.; Gebauer, Niklas

2024 Leukemia

doi:10.1038/s41375-024-02240-8 pmid:38600314

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) constitutes a rare and aggressive malignancy originating from plasmacytoid dendritic cells (pDCs) with a primarily cutaneous tropism followed by dissemination to the bone marrow and other organs. We conducted a genome-wide analysis of the tumor...
Open Access

Journal Article

Fluorescence in situ hybridization reveals the evolutionary biology of minor clone of gain/amp(1q) in multiple myeloma

Cui, Jian; Liu, Yuntong; Lv, Rui; Yan, Wenqiang; Xu, Jingyu; Li, Lingna; Du, Chenxing; Yu, Tengteng; Zhang, Shuaishuai; Deng, Shuhui; Sui, Weiwei; Hao, Mu; Yi, Shuhua; Zou, Dehui; Qiu, Lugui; Xu, Yan; An, Gang

2024 Leukemia

doi:10.1038/s41375-024-02237-3 pmid:38609496

Growing evidence suggests that gain or amplification [gain/amp(1q)] accumulates during disease progression of multiple myeloma (MM). Previous investigations have indicated that small gain/amp(1q) subclones present at the time of diagnosis may evolve into dominant clones upon MM relapse. However,...
Open Access

Journal Article

Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia

Noronha, Nandita; Durette, Chantal; Cahuzac, Maxime; E Silva, Bianca; Courtois, Justine; Humeau, Juliette; Sauvat, Allan; Hardy, Marie-Pierre; Vincent, Krystel; Laverdure, Jean-Philippe; Lanoix, Joël; Baron, Frédéric; Thibault, Pierre; Perreault, Claude; Ehx, Gregory

2024 Leukemia

doi:10.1038/s41375-024-02250-6 pmid:38627586

The hypomethylating agent 5-azacytidine (AZA) is the first-line treatment for AML patients unfit for intensive chemotherapy. The effect of AZA results in part from T-cell cytotoxic responses against MHC-I-associated peptides (MAPs) deriving from hypermethylated genomic regions such as...
Open Access

Journal Article

Combination p53 activation and BCL-xL/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia

Bell, Hayden L.; Blair, Helen J.; Jepson Gosling, Samantha J.; Galler, Martin; Astley, Daniel; Moorman, Anthony V.; Heidenreich, Olaf; Veal, Gareth J.; van Delft, Frederik W.; Lunec, John; Irving, Julie A. E.

2024 Leukemia

doi:10.1038/s41375-024-02241-7 pmid:38600316

Due to the rarity of TP53 mutations in acute lymphoblastic leukemia (ALL), p53 re-activation by antagonism of the p53-MDM2 interaction represents a potential therapeutic strategy for the majority of ALL. Here, we demonstrate the potent antileukemic activity of the MDM2 antagonist idasanutlin in...
Open Access

Journal Article

Combination therapies with ponatinib and asciminib in a preclinical model of chronic myeloid leukemia blast crisis with compound mutations

Curik, Nikola; Laznicka, Adam; Polivkova, Vaclava; Krizkova, Jitka; Pokorna, Eva; Semerak, Pavel; Suchankova, Pavla; Burda, Pavel; Hochhaus, Andreas; Machova Polakova, Katerina

2024 Leukemia

doi:10.1038/s41375-024-02248-0 pmid:38615117
Open Access

Journal Article

Loss of hematopoietic progenitors heterogeneity is an adverse prognostic factor in lower-risk myelodysplastic neoplasms

Dussiau, Charles; Comont, Thibault; Knosp, Camille; Vergnolle, Inès; Bravetti, Clotilde; Canali, Alban; Houvert, Amandine; Largeaud, Laetitia; Daveaux, Christian; Zaroili, Laila; Friedrich, Chloé; Boussaid, Ismaël; Zalmai, Loria; Almire, Carole; Rauzy, Odile; Willems, Lise; Birsen, Rudy; Bouscary, Didier; Fontenay, Michaela; Kosmider, Olivier; Chapuis, Nicolas; Vergez, François

2024 Leukemia

doi:10.1038/s41375-024-02234-6 pmid:38575672

Myelodysplastic neoplasms (MDS) are characterized by clonal evolution starting from the compartment of hematopoietic stem and progenitors cells (HSPCs), leading in some cases to leukemic transformation. We hypothesized that deciphering the diversity of the HSPCs compartment may allow for the...
Open Access

Journal Article

High-plex imaging and cellular neighborhood spatial analysis reveals multiple immune escape and suppression patterns in diffuse large B-cell lymphoma

Reiss, David J.; Nakayama, Yumi; Weng, Andrew P.; Stokes, Matthew E.; Sehn, Laurie; Steidl, Christian; Scott, David W.; Huang, C. Chris; Gandhi, Anita K.

2024 Leukemia

doi:10.1038/s41375-024-02239-1 pmid:38575670
Open Access

Journal Article

Treatment patterns for AL amyloidosis after frontline daratumumab, bortezomib, cyclophosphamide, and dexamethasone treatment failures

Zanwar, Saurabh; Gertz, Morie A.; Muchtar, Eli; Buadi, Francis K.; Kourelis, Taxiarchis; Gonsalves, Wilson; Go, Ronald S.; Hayman, Suzanne; Kapoor, Prashant; Binder, Moritz; Cook, Joselle; Dingli, David; Leung, Nelson; Lin, Yi; Warsame, Rahma; Fonder, Amie; Hobbs, Miriam; Hwa, Yi Lisa; Kyle, Robert A.; Rajkumar, S. Vincent; Kumar, Shaji; Dispenzieri, Angela

2024 Leukemia

doi:10.1038/s41375-024-02243-5 pmid:38594348

results per page

Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Leukemia

Related Journals:

Advanced Search

Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Leukemia

Related Journals:

Our policy towards the use of cookies