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Journal of Radiation Research

Subject Areas: Health, Toxicology and Mutagenesis; ; ; ;
Publisher: Oxford University Press - Oxford University Press
ISSN: 0449-3060
SJR: 63

Open Access

Journal Article

Anti-radiation effect of MRN-100: a hydro-ferrate fluid, in vivo

Ghoneum, Mamdooh; Badr El-Din, Nariman K; Alaa El-Dein, Mai

2024 Journal of Radiation Research

doi:10.1093/jrr/rrad095 pmid:38247158

Ionizing radiation (IR) severely harms many organs, especially the hematopoietic tissue, mandating the development of protective nutraceuticals. MRN-100, a hydro-ferrate fluid, has been shown to protect γ-radiated fish against hematopoietic tissue damage and lethality. The current study aimed to...
Open Access

Journal Article

Enhanced induction of abnormal telomere FISH signals in response to oxidative DNA damage

Sakamoto, Yoshimi; Shiraishi, Kazunori; Kodama, Seiji

2024 Journal of Radiation Research

doi:10.1093/jrr/rrad102 pmid:38171574

Telomere dysfunction induces chromosomal instability, which is a driving force in the development of cancers. To examine X-irradiation’s effect on telomere integrity, we investigated X-ray-induced abnormalities in telomere signals detected by fluorescence in situ hybridization (telomere FISH) in...
Open Access

Journal Article

Application of a derivative of human defensin 5 to treat ionizing radiation-induced enterogenic infection

Zhao, Gaomei; He, Yingjuan; Chen, Yin; Jiang, Yiyi; Li, Chenwenya; Xiong, Tainong; Han, Songling; He, Yongwu; Gao, Jining; Su, Yongping; Wang, Junping; Wang, Cheng

2024 Journal of Radiation Research

doi:10.1093/jrr/rrad104 pmid:38264835

Enterogenic infection is a common complication for patients with radiation injury and requires efficient therapeutics in the clinic. Herein, we evaluated the promising drug candidate T7E21RHD5, which is a peptide derived from intestinal Paneth cell-secreted human defensin 5. Oral administration...
Open Access

Journal Article

MHY1485 potentiates immunogenic cell death induction and anti-cancer immunity following irradiation

Sun, Lue; Morikawa, Kumi; Sogo, Yu; Sugiura, Yuki

2024 Journal of Radiation Research

doi:10.1093/jrr/rrad107 pmid:38330507

Recent in vitro experiments showed that combined treatment with MHY1485, a low-molecular-weight compound, and X-ray irradiation significantly increased apoptosis and senescence in tumor cells, which was associated with oxidative stress, endoplasmic reticulum (ER) stress and p21 stabilization,...
Open Access

Journal Article

Effect of bolus materials on dose deposition in deep tissues during electron beam radiotherapy

Kong, Dong; Wu, Jia; Kong, Xudong; Huang, Jianfeng; Zhao, Yutian; Yang, Bo; Zhao, Qing; Gu, Ke

2024 Journal of Radiation Research

doi:10.1093/jrr/rrae001 pmid:38331401

Several materials are utilized in the production of bolus, which is essential for superficial tumor radiotherapy. This research aimed to compare the variations in dose deposition in deep tissues during electron beam radiotherapy when employing different bolus materials. Specifically, the study...
Open Access

Journal Article

Cone-beam computed tomography-guided online adaptive radiotherapy for pharyngeal cancer with whole neck irradiation: dose-volume histogram analysis between adapted and scheduled plans

Uehara, Takuya; Nishimura, Yasumasa; Ishikawa, Kazuki; Inada, Masahiro; Matsumoto, Kenji; Doi, Hiroshi; Monzen, Hajime; Matsuo, Yukinori

2024 Journal of Radiation Research

doi:10.1093/jrr/rrad103 pmid:38264828

The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated on the...
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Journal Article

The Japanese nationwide cohort data of proton beam therapy for liver oligometastasis in breast cancer patients

Yamaguchi, Hisashi; Fukumitsu, Nobuyoshi; Numajiri, Haruko; Ogino, Hiroyuki; Okimoto, Tomoaki; Ogino, Takashi; Suzuki, Motohisa; Murayama, Shigeyuki

2024 Journal of Radiation Research

doi:10.1093/jrr/rrad106 pmid:38321606

A nationwide multicenter cohort study on particle therapy was launched by the Japanese Society for Radiation Oncology in Japan in May 2016. We analyzed the outcome of proton beam therapy (PBT) for liver oligometastasis in breast cancers. Cases in which PBT was performed at all Japanese proton...
Open Access

Journal Article

Albumin–bilirubin score is a useful predictor of worsening liver reserve after stereotactic body radiation therapy in elderly Japanese patients with hepatocellular carcinoma

Yoshino, Yuki; Suzuki, Gen; Shiomi, Hiroya; Kimoto, Takuya; Seri, Sho; Yamazaki, Hideya; Yamada, Kei

2024 Journal of Radiation Research

doi:10.1093/jrr/rrae006 pmid:38415344

The prognosis of patients with hepatocellular carcinoma (HCC) is closely related to their liver reserves. The Child-Pugh (CP) score has traditionally been used to evaluate this reserve, with CP Grade B (CP score ≥ 7) associated with a higher risk of radiation-induced liver disease after...
Open Access

Journal Article

An analysis of muscle growth after proton beam therapy for pediatric cancer

Nitta, Hazuki; Mizumoto, Masashi; Li, Yinuo; Oshiro, Yoshiko; Fukushima, Hiroko; Suzuki, Ryoko; Hosaka, Sho; Saito, Takashi; Numajiri, Haruko; Kawano, Chie; Kamizawa, Satoshi; Maruo, Kazushi; Sakurai, Hideyuki

2024 Journal of Radiation Research

doi:10.1093/jrr/rrad105 pmid:38265112

Retardation of growth and development is a well-known late effect after radiotherapy for pediatric patients. The goal of the study was to examine the effect of proton beam therapy (PBT) on the growth of muscles included in the irradiated area. The subjects were 17 pediatric patients (age ≤ 5...
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Journal Article

Evaluating thyroid cancer risks for nuclear workers related to the Fukushima Daiichi Nuclear Power Plant accident based on LNT theory is problematic

Scott, Bobby R

2024 Journal of Radiation Research

doi:10.1093/jrr/rrae002 pmid:38321603

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