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Journal of Natural Medicines

Subject Areas: Organic Chemistry; ; ; ; ; ;
Publisher: Springer Nature Singapore - Springer Journals
ISSN: 1340-3443
SJR: 50

Open Access

Journal Article

Correction: Preparation and pharmaceutical properties of Hangeshashinto oral ointment and its safety and efficacy in Syrian hamsters with 5-fluorouracil-induced oral mucositis

Ogihara, Takashi; Kagawa, Masato; Yamanaka, Rintarou; Imai, Satoshi; Itohara, Kotaro; Hira, Daiki; Nakagawa, Shunsaku; Yonezawa, Atsushi; Ito, Michiho; Nakagawa, Takayuki; Terada, Tomohiro; Matsubara, Kazuo

2024 Journal of Natural Medicines

doi:10.1007/s11418-024-01806-1 pmid:38564156
LitStream

Journal Article

Proposal for structure revision of pinofuranoxin A through total syntheses of stereoisomers

Ujiie, Kazuki; Tanaka, Chiaki; Arai, Masayoshi; Hashimoto, Masaru; Yoshida, Yuki; Kawano, Tomikazu; Tamura, Satoru

2024 Journal of Natural Medicines

doi:10.1007/s11418-024-01810-5 pmid:38587582

The relative configuration of the epoxide functionality in pinofuranoxin A (1), α-alkylidene-β-hydroxy-γ-methyl-γ-butyrolactone with trans-epoxy side chain isolated by Evidente et al. in 2021, was revised by DFT-based spectral reinvestigations and stereo-controlled synthesis. The present...
LitStream

Journal Article

Vincarostine A, a novel anti-malarial trimeric monoterpenoid indole alkaloid from Catharanthus roseus

Hirasawa, Yusuke; Kakizoe, Yusuke; Tougan, Takahiro; Uchiyama, Nahoko; Horii, Toshihiro; Morita, Hiroshi

2024 Journal of Natural Medicines

doi:10.1007/s11418-024-01795-1 pmid:38564155

A novel trimeric monoterpenoid indole alkaloid, vincarostine A (1) consisting of an aspidosperma-iboga-aspidosperma type skeleton, was isolated from the whole plant of Catharanthus roseus. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and CD spectrum....
LitStream

Journal Article

Compound–compound interaction analysis of baicalin and berberine derivatives in aqueous solution

Uekusa, Yoshinori; Tanioka, Chiharu; Nakamoto, Kenjiro; Tsutsumi, Riina; Iida, Chihiro; Enshu, Naoto; Nishimura, Takehiro; Kiuchi, Fumiyuki; Kikuchi, Haruhisa

2024 Journal of Natural Medicines

doi:10.1007/s11418-024-01804-3 pmid:38573419

Baicalin and berberine are biologically active constituents of the crude drugs Scutellaria root and Coptis rhizome/Phellodendron bark, respectively. Baicalin and berberine are reported to combine together as a 1:1 complex that forms yellow precipitates by electrostatic interaction in decoctions...
LitStream

Journal Article

Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino

Morikawa, Toshio; Inoue, Naoki; Yamamoto, Saya; Shiotani, Miyuki; Manse, Yoshiaki; Ninomiya, Kiyofumi

2024 Journal of Natural Medicines

doi:10.1007/s11418-024-01799-x pmid:38575838

Methanol extract of the Cnidium officinale Makino rhizome, which is used as a crude drug Cnidium Rhizome (Cnidii Rhizoma; “Senkyu” in Japanese) and is listed in the Japanese Pharmacopoeia XVIII, showed intracellular triglyceride metabolism-promoting activity in high glucose-pretreated HepG2...
Open Access

Journal Article

Correction: Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber

Liu, Yan; Nose, Itsuki; Terasaka, Kazuyoshi; Fueki, Tsukasa; Makino, Toshiaki

2024 Journal of Natural Medicines

doi:10.1007/s11418-024-01808-z pmid:38568472
LitStream

Journal Article

Cryptobuchanosides A–G: seven previously undescribed triterpene glycosides from Cryptolepis buchananii R.Br. ex Roem. and Schult. with nitric oxide production inhibition activity

Bang, Ngo Anh; Duy, Nguyen Duc; Tai, Bui Huu; Thuy, Nguyen Thi Kim; Yen, Pham Hai; Dung, Duong Thi; Hoang, Nguyen Huy; Nhiem, Nguyen Xuan; Ban, Ninh Khac; Van Kiem, Phan

2024 Journal of Natural Medicines

doi:10.1007/s11418-024-01805-2 pmid:38573418

In this study, nine triterpene glycosides including seven previously undescribed compounds (1–7), were isolated from leaves of Cryptolepis buchananii R.Br. ex Roem. and Schult. using various chromatographic methods. The chemical structures of the compounds were elucidated to be...
LitStream

Journal Article

Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption

Miyasaka, Kenchi; Takada, Ryuya; Wu, Jianbo; Takeda, Shogo; Manse, Yoshiaki; Morikawa, Toshio; Shimoda, Hiroshi

2024 Journal of Natural Medicines

doi:10.1007/s11418-024-01791-5 pmid:38587581

Mountain caviar is a fruit of Kochia scoparia that contains momordin Ic as a major saponin constituent. Its extract (MCE) has been shown to suppress blood glucose elevations in the human oral glucose tolerance test (OGTT) as well as increases in blood glucose in OGTT, gastric emptying (GE), and...
Open Access

Journal Article

Correction: Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content

Kudo, Yoshitomi; Ando, Hirokazu; Kaneda, Ai; Ito, Honoka; Umemoto, Kazuki; Ni, Si-ran; Mikage, Masayuki; Sasaki, Yohei

2024 Journal of Natural Medicines

doi:10.1007/s11418-024-01807-0 pmid:38568473
LitStream

Journal Article

New biflavonoids isolated from Xylia kerrii leaves extract with selective cytotoxicity against MH7A human rheumatoid arthritis synovial fibroblast cells

Fujii, Kazuki; Iwata, Itsuki; Takaya, Akiko; Ishibashi, Masami; Hara, Yasumasa

2024 Journal of Natural Medicines

doi:10.1007/s11418-024-01801-6 pmid:38592349

Three new biflavonoids (1–3) and two known flavonoids (4, 5) were isolated from Xylia kerrii collected in Thailand. Compounds 1–5 showed selective cytotoxicity against the rheumatoid fibroblast-like synovial MH7A cell line, and these compounds showed weak cytotoxicity against the human lung...

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