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Rethrombosis may be a major determinant of poor outcome after angioplasty. Fibrinopeptide A, a marker of thrombin activity, was measured in 79 patients after coronary angioplasty to assess for association with subsequent cardiac events. Fibrinopeptide A levels were drawn postangioplasty on...
Percutaneous transluminal coronary angioplasty may be complicated by the occurrence of major coronary artery dissection, which may precipitate critical myocardial ischemia, necessitating urgent surgical intervention. We report two cases of massive dissection following angioplasty, in which novel...
Large controlled mortality studies with streptokinase, APSAC or tissue plasminogen activator (tPA) have conclusively shown that thrombolytic therapy within 6 hours after symptom onset improves survival after acute myocardial infarction. There is evidence of benefit even for patients treated...
The proliferation of sophisticated endovascular interventions is mandating more definitive and comprehensive documentation of atherosclerotic lesions and the results of the interventional devices used in their removal. A technique with a potential to fulfill these goals, intravascular ultrasound...
Streptokinase (SK) and tissue plasminogen activator (alteplase (tPA)) are by far the most intensively studied thrombolytic agents, but only recently a direct head‐to‐head comparison (GISSI‐2 Trial, in which 12,490 patients have been randomized) has become available to the scientific community....
Changes in a coronary artery thrombus resulting from platelet activation may affect the speed of thrombolysis and the frequency of reocdusion after thrombolytic therapy. In studies performed in canine models, we have found that selected thromboxane and serotonin receptor antagonists given in...
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