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Innate Immunity Volume 27 Issue 5

Subject Areas: Cell Biology; ; ; ; ; ;
Publisher: SAGE PublicationsSage UK: London, England - SAGE
ISSN: 1753-4259
SJR: 72

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Journal Article

Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation:

Wilkinson, Melissa L; Gow, Andrew J

2021 Innate Immunity

doi:10.1177/17534259211015330 pmid:34375151

Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins via a Michael addition on nucleophilic...
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Journal Article

Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population:

Varzari, Alexander; Deyneko, Igor V.; Tudor, Elena; Grallert, Harald; Illig, Thomas

2021 Innate Immunity

doi:10.1177/17534259211029996 pmid:34275341

Polymorphisms in genes that control immune function and regulation may influence susceptibility to pulmonary tuberculosis (TB). In this study, 14 polymorphisms in 12 key genes involved in the immune response (VDR, MR1, TLR1, TLR2, TLR10, SLC11A1, IL1B, IL10, IFNG, TNF, IRAK1, and FOXP3) were...
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Journal Article

Long non-coding RNA ZFAS1 alleviates sepsis-induced myocardial injury via target miR-34b-5p/SIRT1:

Chen, Dan-Dan; Wang, Hong-Wu; Cai, Xing-Jun

2021 Innate Immunity

doi:10.1177/17534259211034221 pmid:34340571

Long non-coding RNA ZFAS1 is down-regulated in sepsis. However, whether ZFAS1 participates in sepsis-induced cardiomyopathy (SIC) remains largely unknown. LPS injection to rats was used to establish an in vivo sepsis model, while LPS stimulation with H9C2 cell was used to mimic an in vitro...
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Journal Article

Does chronic dietary exposure to the mycotoxin deoxynivalenol affect the porcine hepatic transcriptome when an acute-phase response is initiated through first or second-pass LPS challenge of the liver?:

Dänicke, Sven; Heymann, Ann-Katrin; Oster, Michael; Wimmers, Klaus; Tesch, Tanja; Bannert, Erik; Bühler, Susanne; Kersten, Susanne; Frahm, Jana; Kluess, Jeannette; Kahlert, Stefan; Rothkötter, Hermann-Josef; Billenkamp, Fabian

2021 Innate Immunity

doi:10.1177/17534259211030563 pmid:34338001

The sensitivity of pigs to deoxynivalenol (DON) might be increased by systemic inflammation (SI), which also has consequences for hepatic integrity. Liver lesions and a dys-regulated gene network might hamper hepatic handling and elimination of DON whereby the way of initiation of hepatic...
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Journal Article

The TNF-α (–238 G/A) polymorphism could protect against development of severe sepsis:

Montes, A. Hugo; Valle-Garay, Eulalia; Martin, Guadalupe; Collazos, Julio; Alvarez, Victoria; Meana, Alvaro; Pérez-Is, Laura; Carton, José A.; Taboada, Francisco; Asensi, Víctor

2021 Innate Immunity

doi:10.1177/17534259211036186 pmid:34472396

Primary responses in sepsis-mediated inflammation are regulated by pro-inflammatory cytokines. Variations in the cytokine genes might modify their transcription or expression, plasma cytokines levels and response to sepsis. Activation protein-1 (AP-1) and NF-κB regulate cytokines gene expression...

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