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The intimate mechanisms involved in aortic valve calcification (AVC) are not completely known. It is more evident to suggest that cardiovascular calcification is an inflammatory condition. Tumor necrosis factor alpha (TNF-α), a pro-inflammatory cytokine, is increased in valvular lesions besides...
Serum response factor (SRF) is an ubiquitously expressed member of the MADS (MCM1, Agamous, Deficiens, SRF) box transcription factor family, sharing a highly conserved DNA-binding/dimerization domain, which binds the core sequence of SRE/CArG boxes (CC (A/T)6 GG). In addition, SRF is as well a...
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