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Acridine has been found to undergo readily concurrent N(1)- and С(9)-functionalization under the action of ethyl aryl-2-oxobut-3-ynoates and water to form pharmacologically promising previously unknown N-alkenylacridones in 80–84% yields.
An approach was developed for the synthesis of multitarget compounds based on a tacrine molecule conjugated with a vanillin moiety using alkylimine or alkylamine linkers with different alkyl chain lengths (C2–C4). The synthesized conjugates effectively inhibit cholinesterases, displace propidium...
The efficient synthetic approaches to new 2,2'-bipyridine ligands functionalized with a 3-thienyl moiety have been developed. These compounds are of interest as monomeric units for electropolymerization. The “1,2,4-triazine” methodology was used for the synthesis.
A method for preparing 1-tosyl-3H-naphtho[1,2,3-de]quinoline-2,7-diones by the reaction of N-(9,10-anthraquinon-1-yl)chloroacetamide with sodium p-toluenesulfinate has been developed. Nucleophilic substitution of the tosyl group by nitrogen and oxygen nucleophiles has been found to proceed under...
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