Current Opinion in Endocrinology Diabetes and Obesity Volume 7 Issue 6

Journal Article

Physiological actions of parathyroid hormone related protein

Nissenson, Robert A.

2000 Current Opinion in Endocrinology & Diabetes

Since it was discovered that parathyroid hormone related protein (PTHrP) is the major mediator of hypercalcemia of malignancy, there has been intense interest in defining the biological roles and mechanism action of the protein. Gene-knockout studies demonstrated that a functional

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Journal Article

Osteoporosis in men

Orwoll, Eric S.

2000 Current Opinion in Endocrinology & Diabetes

Osteoporosis in men has become much more prominent as its prevalence and impact have become apparent. Fractures in men are common and of great importance to both individuals and society. Although in many ways the character of osteoporosis in men is similar to that in women, there are important...

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Journal Article

New therapies for the prevention and treatment of osteoporosis

Schneider, Diane L.

2000 Current Opinion in Endocrinology & Diabetes

Osteoporosis is a common disease in postmenopausal women and can result in considerable morbidity and mortality as a consequence of spontaneous fractures. Fortunately, effective therapeutic agents that prevent or slow bone resorption are now available for the prevention and treatment of...

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Journal Article

Glucocorticoid-induced osteoporosis

Canalis, Ernesto

2000 Current Opinion in Endocrinology & Diabetes

Glucocorticoids cause profound effects on bone resorption and formation that result in osteoporosis. Glucocorticoids increase bone resorption by stimulating new osteoclastogenesis. This seems to be due to an increase in osteoclast differentiation factor and a decrease in osteoprotegerin....

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Journal Article

Controversies in postmenopausal hormone replacement

Martin, Kathryn A.

2000 Current Opinion in Endocrinology & Diabetes

Short-term hormone replacement therapy (HRT) in postmenopausal women is effective for the treatment of estrogen deficiency symptoms such as vasomotor flushes and vaginal dryness. Most practitioners would agree that short-term use (up to 3 years) of HRT (combined estrogen and progestin for those...

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Journal Article

Mechanisms and treatment of androgen deficiency in HIV disease

Grinspoon, Steven

2000 Current Opinion in Endocrinology & Diabetes

Hypogonadism is common among men with HIV disease, particularly among those with the AIDS wasting syndrome. The mechanisms of androgen deficiency in this population remain unknown but may relate to the effects of chronic illness per se, poor nutrition, cytokines, or specific drugs used in the...

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Journal Article

Physiology and pathophysiology of inhibin A and activin A in human pregnancy

Lambert-Messerlian, Geralyn

2000 Current Opinion in Endocrinology & Diabetes

With the advent of immunoassays specific for inhibin A and activin A, much has been learned about the role of these proteins in female physiology. Both are prominent products of the placenta and, as such, can be found in high concentrations in maternal serum throughout pregnancy. This has led to...

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Journal Article

Insulin resistance and the polycystic ovary syndrome&colon; recent advances

Nestler, John E.

2000 Current Opinion in Endocrinology & Diabetes

The polycystic ovary syndrome is a prevalent disorder characterized by chronic anovulation and hyperandrogenism. It has recently been appreciated that insulin resistance with a compensatory hyperinsulinemia is also a prominent feature of the disorder and plays a key role in its development in...

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Journal Article

Gonadotropin-releasing hormone antagonists

Fluker, Margo R.

2000 Current Opinion in Endocrinology & Diabetes

Nearly 3 decades have elapsed since the initial characterization of native gonadotropin-releasing hormone. Numerous agonistic and antagonistic analogues have been synthesized in the interim and have been used to manipulate the menstrual cycle and treat various steroid-dependent disorders. The...

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Current Opinion in Endocrinology Diabetes and Obesity Volume 7 Issue 6

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Current Opinion in Endocrinology Diabetes and Obesity Volume 7 Issue 6

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