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Cancer Biomarkers

Subject Areas: Cancer Research; ; ; ;
Publisher: IOS Press - IOS Press
ISSN: 1574-0153
SJR: 46

LitStream

Journal Article

Subgroup identification of targeted therapy effects on biomarker for time to event data

Vishwakarma, Gajendra K.; Bhattacharjee, Atanu; Tank, Fatih; Pashchenko, Alexander F.

2023 Cancer Biomarkers

doi:10.3233/cbm-230181 pmid:37980650

BACKGROUND:The initiation biomarker-driven trials have revolutionized oncology drug development by challenging the traditional phased approach and introducing basket studies. Notable successes in non-small cell lung cancer (NSCLC) with ALK, ALK/ROS1, and EGFR inhibitors have prompted the need to...
LitStream

Journal Article

Albumin-bilirubin score predicts trastuzumab resistance in HER2-positive breast cancer

Huang, Wen-Juan; Yuan, Jia-Rui; Zhang, Lei; Wang, Wen; Miao, Shi-Di; Wang, Xin; Wang, Rui-Tao

2023 Cancer Biomarkers

doi:10.3233/cbm-230077 pmid:37980647

BACKGROUND:The albumin-bilirubin (ALBI) score is a novel indicator of liver function. Some studies showed that the ALBI score was a predictive marker for the prognosis and efficacy of drug therapy in malignancies. We aimed to assess the predicted role of ALBI score in the sensitivity to therapy...
LitStream

Journal Article

HPV genotype-specific distribution and attributable risk in cervical intraepithelial neoplasia in a referral population with a history of LSIL

Ratnam, Sam; Jang, Dan; Alaghehbandan, Reza; Gilbert, Laura; Xu, Yunwen; Wang, Wei; Andrews, Phillip; Green, Ashley; Speicher, David J.; Chernesky, Max

2023 Cancer Biomarkers

doi:10.3233/cbm-220470 pmid:37980645

BACKGROUND AND OBJECTIVE:CINtec PLUS and cobas HPV tests (Roche) were previously ascertained for triaging an LSIL referral population [1]. As part of this study, genotype-specific distribution and attributable risk of high-risk (HR)-HPV in cervical intraepithelial neoplasia (CIN) were...
LitStream

Journal Article

Integrative analysis of histone acetyltransferase KAT2A in human cancer

Li, Hua; Li, Chun; Yang, Lu-Zong; Liu, Ji

2023 Cancer Biomarkers

doi:10.3233/cbm-220464 pmid:38007639

The high incidence of mutations and the crucial roles of KAT2A in cancer development have received increased attention. Nevertheless, a systematic comparison of the heterogeneity and dynamics across different cancer types has not been conducted. Hence, a deep analysis using public databases was...
LitStream

Journal Article

A comprehensive analysis of mRNA expression profiles of Esophageal Squamous Cell Carcinoma reveals downregulation of Desmoglein 1 and crucial genomic targets

Alotaibi, Amal; Gadekar, Veerendra P.; Gundla, Pranav Swaroop; Mandarthi, Sumana; Ravi, Subramanyeshwari; Mallya, Dhyeya; Tungekar, Asna; Lavanya, B.V.; Bhagavath, Ashok Kumar; Cordero, MaryAnne Wong; Pitkaniemi, Janne; Seetharam, Raviraja N.; Bepari, Asmatanzeem; Hebbar, Prashantha

2023 Cancer Biomarkers

doi:10.3233/cbm-230145 pmid:38073377

AIM:Esophageal Squamous Cell Carcinoma (ESCC) is a histological subtype of esophageal cancer that begins in the squamous cells in the esophagus. In only 19% of the ESCC-diagnosed patients, a five-year survival rate has been seen. This necessitates the identification of high-confidence biomarkers...
LitStream

Journal Article

Correlation between IL3 signaling pathway-related genes and immune checkpoint inhibitor efficacy in patients with renal cell carcinoma

Hou, Shuang; Gu, Tianqi; Shi, Ying; Huang, Yushan; Yao, Jiarong; Luo, Peng; Cao, Manming; Zhang, Jian; Lin, Anqi; Zhu, Weiliang

2023 Cancer Biomarkers

doi:10.3233/cbm-230226 pmid:38043008

BACKGROUND:There is a lack of effective biomarkers that predict immunotherapy efficacy in clear cell renal cell carcinoma(KIRC).OBJECTIVE:We aimed to identify biomarkers that would predict the efficacy of KIRC treatment with immune checkpoint inhibitors (ICIs).METHODS:Cohort data of KIRC patients...
LitStream

Journal Article

STEAP3 is a prognostic biomarker that promotes glioma progression by regulating immune microenvironment and PI3K-AKT pathway

Song, Zihan; Zhao, Zijun; Zhu, Siyu; Jin, Qianxu; Shi, Yunpeng; Zhang, Shiyang; Wang, Zairan; Wang, Yizheng; Zhao, Zongmao

2023 Cancer Biomarkers

doi:10.3233/cbm-230217 pmid:37980651

BACKGROUND:STEAP3 is a metal reductase located on the plasma membrane close to the nucleus and vesicles. Despite numerous studies indicating the involvement of STEAP3 in tumor advancement, the prognostic value of STEAP3 in glioma and the related mechanisms have not been fully...
LitStream

Journal Article

Identification of the six-hormone secretion-related gene signature as a prognostic biomarker for colon adenocarcinoma

Jia, Xiongjie; Zhang, Tao; Lv, Xinze; Du, Haiwei; Sun, Yongkun; Guan, Yin

2023 Cancer Biomarkers

doi:10.3233/cbm-230126 pmid:38143338

BACKGROUND:Colon adenocarcinoma (COAD) is a globally prevalent cancer, with hormone secretion playing a crucial role in its progression. Despite this, there is limited understanding of the impact of hormone secretion on COAD prognosis. This study aimed to establish a prognostic signature based on...
LitStream

Journal Article

The clinical value of a nomogram constructed from CEA, CA199, PT, FIB, tumor differentiation and TNM stage in colorectal cancer

Wang, Kang; Ma, Lulu; Chen, Liying; Jiang, Yatong; Liu, Ningquan; Cai, Jianchun; Zhang, Yiyao

2023 Cancer Biomarkers

doi:10.3233/cbm-230116 pmid:37980649

BACKGROUND:The accurate Tumor-Node-Metastasis (TNM) staging of colorectal cancer (CRC) is of great guiding significance for the judgment of tumor progression and prognosis, and the formulation of treatment strategies.OBJECTIVE:The aim of this study was to construct a recurrence risk scoring (RRS)...
LitStream

Journal Article

The identification of N6-methyladenosine-related miRNAs predictive of hepatocellular carcinoma prognosis and immunotherapy efficacy

Zou, Renrui; Liu, Yaqian; Qiu, Sangsang; Lu, Ya; Chen, Yan; Yu, Hui; Zhu, Hangju; Zhu, Wenbo; Zhu, Longbiao; Feng, Jifeng; Han, Jing

2023 Cancer Biomarkers

doi:10.3233/cbm-230263 pmid:38007640

BACKGROUND:Hepatocellular carcinoma (HCC) has a high degree of malignancy and poor prognosis. N6-methyladenosine (m6A) modifications and microRNAs (miRNAs) play pivotal roles in tumorigenesis and development. However, the role of m6A-related miRNAs in HCC has not been clarified yet. This study...

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