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Treatment of rabbit aortic endothelial cells or human umbilical vein cells for as little as 1 day with 25 μg/ml of β-mlgratlng very low density lipoprotein (β-VLDL), but not low density lipoprotein (LDL), caused an increased binding of human peripheral blood monocytes to the endothellum. This...
We are studying the genetic factors underlying the common forms of heart disease by Identifying genes that affect normal variations in plasma llpid, lipoproteln, and apolipoprotein concentrations In baboons. For these studies we are using cloned human gene probes to Identify restriction fragment...
Olelc acid (181n-9, OA), docosahexaenoic acid (22 6n-3, DHA), or eicosapentaenoic acid (20 5n-3, EPA) was added to HepG2 cells at a concentration of 1 mM In a 5:1 or 2:1 molar complex with bovine serum albumin (BSA), and this was Incubated for 3 hours. The Incorporation of 3H-glycerol Into...
Serum Insulin concentrations are higher In persons with a positive parental history of diabetes than In persons without such a history. Since hyperinsullnemia Is associated with both an increased prevalence of hypertension and an atherogenic pattern of serum lipids and lipoprotelns, we...
Cynomolgus monkeys were given prednlsone to determine its effects on lipoprotein metabolism and other risk factors for atherosclerotic cardiovascular disease. After 1 month of oral prednlsone, the mean total plasma cholesterol (TPC) concentration increased from 240±36 to 476±78 mg/dl (p<0.01) in...
We asked If the arterial sites most prone to early lesions In cholesterol-fed rabbits have higher permeabilities to low density lipoprotein (LDL) In normollpidemlc rabbits or If these sites become more permeable shortly after the onset of cholesterol feeding. We also considered whether the focal...
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