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We have previously observed that cholesterol-fed dogs with plasma cholesterol levels of 350 to 750 mg/dl failed to develop atherosclerosis (hyporesponders), whereas cholesterol-fed dogs with cholesterol levels greater than 750 mg/dl developed markedly accelerated atherosclerosis...
Transluminal angioplasty has shown promise as a nonoperative treatment of atherosclerotic obstruction. Despite its Increasing clinical use and potential Importance, little Is known of its mechanism and acute effects. To evaluate transluminal angioplasty, three rabbit models of experimental...
The ability of macrophages to Influence the metabolism of native low density lipoprotein by arterial smooth muscle cells was evaluated using cultured human monccyte-derlved macrophages. Macrophage-condltloned medium stimulated the binding and degradation of low density lipoprotein by cultured...
A double antibody radioimmunoassay was developed for apolipoprotein A-ll (apo A-ll), one of the two major apoprotelns of human high density lipoproteins (HDL). Apo A-ll contains two identical polypeptide chains linked by a disulflde bond. A specific antlserum was raised in sheep. Tracer apo A-ll...
We studied histamine metabolism, i.e., histldine decarboxylase (HD)-mediated synthesis and hlstamlnase-mediated catabollsm, in relation to intracellular histamine content in both aortic endothelial and subjacent smooth muscle cells of control and diabetic rats. Diabetes was Induced by a single...
We used the Princeton School Family Study hypercholesterolemic recall group to assess whether, and to what degree, the Identification of hypercholesterolemic subjects could be Improved through the phenomenon of familial llpid and llpoproteln aggregation. A second aim was to assess whether...
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