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AbstractQuantitative in vitro to in vivo extrapolation (QIVIVE) is broadly considered a prerequisite bridge from in vitro findings to a dose paradigm. Quality and relevance of cell systems are the first prerequisite for QIVIVE. Information-rich and mechanistic endpoints (biomarkers) improve...
AbstractIntroduction: In vitro substrate depletion methods developed by the pharmaceutical industry are being used with increasing frequency to support chemical bioaccumulation assessments for fish. However, the application of these methods to high log Kow chemicals poses special...
AbstractIntroduction: Development of an in vitro screening assay to predict the neurodegenerative potential of compounds in humans would benefit the safety assessment of pharmaceuticals and industrial chemicals. In this study, we compared the sensitivity of physiologically relevant human-induced...
AbstractIntroduction: Goblet cell hyperplasia (GCH) within the epithelium of the conducting airways is a common feature of human respiratory diseases, including asthma and chronic obstructive pulmonary disease. GCH can be initiated or exacerbated by environmental agents, including air pollution,...
AbstractApproximately 1 million women smoke during pregnancy despite evidence demonstrating serious juvenile and/or adult diseases being linked to early-life exposure to cigarette smoke. Susceptibility could be determined by factors in previous generations, that is, prenatal or “maternal”...
AbstractAirway irritant exposures in the workplace cause sensory irritation symptoms or signs such as nose and throat pain, rhinorrhea, cough, and airway obstruction, and are associated with nonallergic airway hyper-responsiveness. Using toxicity data to derive chemical-specific occupational...
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