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AbstractUsing general cytotoxicity assays in combination with in vitro tests for organ-specific toxicity has been proposed as an alternative approach to animal tests for estimation of acute systemic toxicity. Here, we present the C17.2 neural progenitor cell line as an option for estimation of...
AbstractBetween February 15 and 17, 2016, a workshop was held in London, hosted by Unilever's Safety and Environmental Assurance Centre, which sought to explore determinations of cellular stress as part of the data required for next-generation risk assessments, considering how to define tipping...
AbstractAssessment of novel tobacco and nicotine products for their harm reduction potential compared with cigarettes is of significance for regulators and public health. The National Research Council's report, “Toxicity Testing in the 21st Century,” outlines recent advances in molecular biology...
AbstractThe potential for chemicals to affect endocrine signaling is commonly evaluated via in vitro receptor binding and gene activation, but these assays, especially antagonism assays, have potential artifacts that must be addressed for accurate interpretation. Results are presented from...
AbstractCytosolic Ca2+ is a universal second messenger that is involved in many processes throughout the body, including the regulation of cell growth/cell division, apoptosis, and the secretion of both ions, and macromolecules. Tobacco smoke exerts multiple effects on airway epithelia and we...
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