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AbstractWith the passing of Dr. Gilman D. Veith on August 18, 2013, the research community lost one of its true visionaries in the development and implementation of alternative in silico and in vitro toxicology models in human health and ecological risk assessment. His career spanned more than...
AbstractToday, engineered three-dimensional tissue models from human cells of the skin, cornea, mucosa, and respiratory tract are widely used in pharmaceutical, chemical, consumer, and cosmetic industries as alternatives to animal testing. The currently available scientifically valid 3D...
AbstractEnvironmental influence is a significant factor governing the relationship over an individual's genetic predisposition toward obesity. A largely unexplored avenue is the notion of obesogens: environmental endocrine disrupting chemicals (EDCs) that may alter the propensity toward obesity,...
AbstractImmune-mediated chemical-induced hepatotoxicity is often overlooked as a potential mode of action due to the lack of appropriate in vitro models. For this reason, we have established a coculture system of rat primary hepatocytes and Kupffer cells (KCs) that can be used to examine...
AbstractThe use of human skin models in pharmacology and toxicology has become a widely accepted approach for the evaluation of dermato-cosmetic products, both finished formulations and active ingredients. In particular, in vitro–reconstructed human skin models consisting on human keratinocytes...
AbstractHigh-throughput screening (HTS) assays may provide an efficient way to identify endocrine-active chemicals. However, nominal in vitro assay concentrations of a chemical may not accurately reflect the blood or tissue levels that cause in vivo effects because in vitro assays do not fully...
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