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Estrogen receptor (ER) expression was retrospectively studied by an immunohistochemical method (IHC) on Bouin-Holland fixed, paraffin-embedded tissue sections from 938 primary operable breast cancers resected between 1980 and 1986 (median follow-up, 9 years), in which ER contents were routinely...
O13 (CD99) is a monoclonal antibody directed against the glycoprotein p30/32MIC2. which has been found to be a sensitive marker for Ewing's sarcoma. The reactivity of O13 in spindle cell tumors has not been extensively investigated. We examined the reactivity of O13 in hemangiopericytoma...
We present a case of a solitary pulmonary nodule in a patient with a past history of colonic adenocarcinoma. This case illustrates the problem of discriminating primary lung adenocarcinoma from metastatic colonic carcinoma. This distinction may have both clinical and therapeutic significance for...
The precise relationship between p53 tumor-suppressor gene mutations and immunohistologic detection remains controversial. Technical factors may affect p53 immunoreactivity (IR), including the p53 antibody used, its specificity for mutant p53 protein and/or wild-type protein, and the use of...
A comparative study of antigen unmasking by wet autoclaving and microwave heating so as to immunostain p53was applied to a series of 63 ovarian and cndometrial carcinomas. Wet autoclaving proved to be a rather useful method for restoring p53antigens. One of its main advantages is the...
Terminal deoxynucleotidyl transferase (TdT) is a wellestablished marker of immature hematopoietic cells which is widely used for the diagnosis and characterization of acute leukemias and lymphoid neoplasms. In this review we describe the biology and histopathology of TdT, including a critical...
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