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Book reviewed in this article: Genetic Maps. Locus Maps of Complex Genomes. 5th edition. Edited by Stephen J.O'Brien.
SUMMARY The Kell blood group locus (KEL) is tightly linked to the prolactin‐inducible protein locus (PIP) with ẑ=9.12 at ô= 0.00 for combined paternal and maternal meioses. In view of the regional localization of PIP to 7q32‐q36 (Myal et al. 1989a), a similar assignment for KEL is favoured.
SUMMARY Three different point mutations were recently identified in South African familial hypercholesterolaemics. These mutations result in the modification of recognition sites of specific restriction endonucleases. This study describes rapid methods for presymptomatic detection of these...
SUMMARY We show that data on the frequency of occurrence of an hereditary trait in family members can be used to determine all four parameters in a Mendelian genetic model with incomplete penetrance. Thus previous statements in the literature that such data can determine only three combinations...
SUMMARY The polymorphisms of mitochondrial DNA for the restriction enzymes Hpal, Bamill, Haell, Mspl, Avail and Hindi were studied in a sample of 79 Hindus, 45 from New Delhi (India) and 34 from Terai (Nepal), both to characterize another Caucasian population and to investigate some possible...
SUMMARY EcoRI restriction analysis at codon 4154 of the Apo B gene was performed in a sample of 90 subjects from southern Italy (sample S), using total blood cell DNA amplified by PCR. A group of 46 subjects from northern Italy (sample N) was also investigated for comparison. Southern Italians...
SUMMARY A complex segregation analysis was conducted on two British series (one consecutive series of probands with breast cancer and one series ascertained through a normal consultand). Altogether there were 1248 nuclear families with breast cancer. A dominant gene with a frequency of 0‐003...
SUMMARY The genetic heterogeneity of eleven populations from the Pyrenees (France) based on the polymorphism of the immunoglobulin allotypes is studied by means of a ‘genetic similarity map’. The method described here, called ‘Mobile Node Metho’, allows the deformation of a square grid, in which...
SUMMARY From a lambda Charon 4A library digested with EcoRI, eight human genomic clones have been isolated, each detecting a high frequency RFLP. These phage clones have been assigned to eight different human chromosomes using Southern blot analysis and human‐rodent somatic cell hybrids.
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