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Book reviewed in this article: Molecular Evolutionary Genetics. By M. NEI.
SUMMARH Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is common in Italy and recent biochemical and kinetic studies have demonstrated the presence of polymorphic variants associated with severe or mild enzyme deficiency. We performed a biochemical characterization of G6PD in a large number...
SUMMARY The distribution of surnames of the living immigrants in the population of the town of Ferrara was studied by sex of immigrants and by distance of their place of origin from Ferrara. It was found that isonymy decreases with distance from the place of origin and that there is sexual...
SUMMARY The likelihood method of optimizing the position of loci within a given order using data from pairs of loci is discussed in relation to Fisher's paper of 1922 and to recent data on chromosome 22 in man.
SUMMARY In witro DNA amplification allows multiplication of selected gene segments thereby improving the sensitivity in DNA analysis. Different allelic variants in the amplified DNA may be disclosed either by subsequent hybridization with allele‐specific oligonucleotides or by subsequent...
SUMMARY The logic of a program for multiple pairwise linkage analysis under interference is set forth, including a seriation algorithm to obtain a trial order, a mapping bootstrap to improve the trial order, and three procedures for quality control to detect mistyping. This approach is compared...
SUMMARY A method of analysis of suitable many‐locus linkage data used by Fisher in 1922 is reexamined in detail, and it is pointed out that it could be used also in human genetics as a simple method for preliminary examination of data.
SUMMARY A cDNA clone complementary to the mRNA encoding the sperm‐specific lactate dehydrogenase, LDHC, has been used to map the LDHC locus to the short arm of human chromosome 11. In situ hybridization data and analysis of mouse/human somatic cell hybrids carrying deletions of human chromosome...
SUMMARY A collaborative analysis was undertaken of 226 karyotypes with structural chromosome abnormalities diagnosed primarily with low level banding resolution, about 300 to 400 bands per karyotype. We estimate that in this series, use of low level banding was required to detect about 78% of...
SUMMARY Male and female sibs born to third‐cousin parents presented with mental retardation, microcephaly, short stature, juvenile onset limb‐girdle muscular dystrophy and multiple chromosome mosaicism in lymphocytes and fibroblasts. Different aneuploidies (mostly trisomies) were found in 15–20%...
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