1 - 10 of 14 articles
Book reviews in this articles Gnetics of Neurological and Psychiatric Disorders. Association for Research in Nervous and Mental Disease.
Summary 1. The recently identified χ‐ADH isozyme was purified from human liver and used to raise immune sera. 2. The χ form of ADH showed no structural resemblance to the ADH1, ADH2 and ADH3 (class I) or ADH4 (class II) isozymes, as judged by its immunological properties. 3. χ‐ADH was found in...
Summary A cloned 15 kb genomic fragment from the human α1 (I) collagen gene (COL1A1) has been used as a probe on restriction digests of DNA from human‐mouse somatic cell hybrids. Positive results on hybrids containing chromosome 17 as their only karyotypically visible human material confirm the...
Summary The results of a cytogenetic and segregation analysis of 110 pedigrees of the mar (X) syndrome are reported. The cytogenetic study indicated an inverse relationship between IQ and the mar(X) frequency in females but not in males. A small but significant effect of age on mar(X) frequency...
Summary 1. Three sets of isozymes of glutathione‐S‐transferase (GST) have been identified in human tissues. They differ in their tissue distribution, incidence of genetic variation, susceptibility to inactivation by N‐ethylmaleimide and in their electrophoretic mobilities. 2. The GST1 isozymes...
Summary A model for genetic diseases and associated markers is defined where two distinct susceptibility alleles are possible, each associated with a different marker allele. Marker genotype distributions in a disease population are then expressed in terms of haplotype frequencies and penetrance...
Summary Segregation of biliverdin reductase (BLVR) in 11 independent human‐mouse hybrids confirms the assignment to chromosome 7 in man and gives a regional localization of 7pter → 7q22. Isoelectric focusing of BLVR reveals genetically determined variation among inbred strains of mice.
Summary Peptidase E has been studied in 16 independent human‐Syrian hamster hybrids and 16 subclones. Evidence is presented indicating that the human gene for Peptidase E is on chromosome 17 in the region 17q23 → 17qter.
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