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▴ Gemcitabine has antitumor activity against a range of cancers both alone and in combination with other chemotherapy agents. It is a nucleoside analog prodrug that inhibits DNA synthesis via its active metabolites gemcitabine triphosphate and gemcitabine diphosphate.
▴ Gemcitabine has well established antitumor activity against a variety of solid tumors, including ovarian cancer, and hematologic malignancies. It has recently been approved in several European countries for use with carboplatin for the treatment of advanced ovarian cancer in patients with...
The chimeric anti-CD20 monoclonal antibody rituximab has emerged as an effective single agent for the treatment of patients with CD20-positive indolent lymphoid malignancies (ILM). The purine nucleoside analogs (PNAs) fludarabine, cladribine, and pentostatin are also active agents in ILM and...
Background:The combination of intravenous paclitaxel (three-times weekly administration at a dose of 175 mg/m2) and oral capecitabine has been shown to be highly active in the treatment of advanced or metastatic breast cancer. Currently, there is much interest in the use of relatively low dose...
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