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The human papillomavirus (HPV) has been implicated in the development of an estimated 10% of cancers worldwide. Both epidemiologic and molecular evidence have conclusively demonstrated that oncogenic HPV is the central causal agent of cervical cancer and of a substantial proportion of many other...
The role of chemotherapy in advanced gastric and gastroesophageal junction cancers is evolving. Although there is no established global front-line treatment regimen, combination therapy with fluorouracil and cisplatin is often used as first-line therapy in untreated patients with advanced...
This paper reviews the clinical profile of the neurokinin-1 (NK1) receptor antagonist aprepitant, the first approved antiemetic in its class, developed for use in the prevention of chemotherapy-induced nausea and vomiting (CINV). CINV, which ranges from mild nausea to protracted vomiting with...
Worldwide, colorectal cancer ranks third in terms of both incidence and mortality and is the second most prevalent cancer after breast cancer. There is an estimated 2.4 million people alive with the disease diagnosed in the previous 5 years. Chemotherapy has been shown to improve time to disease...
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