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In the increasing search for cancer-specific vulnerabilities, considerable attention has been focused in the past few years on telomeres, the natural termini of eukaryotic chromosomes which are maintained by the enzymatic complex telomerase. The limited capacity to divide is a long-recognized...
Review of current data on gemcitabine (Gemzar®) in non-small cell lung cancer
Uterine sarcomas comprise 2–3% of all uterine malignancies. Tumors in this category are, in order of decreasing incidence, carcinosarcoma, leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. Endometrial stromal sarcomas are divided into low- and high-grade according to tumor cell...
Review of current data on pemetrexed (Alimta® ) in the treatment of lung cancer
An understanding of the pathophysiology of bone metastases requires a knowledge of normal and abnormal bone remodeling. This knowledge is helpful in understanding mechanisms of action of bone active agents such as bisphosphonates. When malignant cells infiltrate bone spaces, the balance of bone...
Primary central nervous system (CNS) germinoma is readily curable with relatively large volume/high dose radiotherapy but the late effects of treatment may alter neurocognitive functioning and quality of life. Prior studies have associated radiation therapy with deficits in the domains of...
The management of multiple myeloma (MM) has undergone many developments in the last 30 years. Initially, melphalan was used as a single agent and this was followed by the discovery of corticosteroids as highly active agents and the design of multiagent cytotoxic regimens. However, although...
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