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Epithelial ovarian cancer (EOC) is the most common cause of death from gynecological malignancy in the industrialized world. Most patients present with advanced disease and, despite optimal surgical debulking and front-line chemotherapy with platinum- and taxane-based regimens, the majority will...
Hairy cell leukemia is a B cell malignancy, accounting for 2% of all leukemias. Patients typically have splenomegaly, pancytopenia and an indolent course. Diagnosis requires identification of malignant cells in the bone marrow and peripheral blood with cytoplasmic projections and characteristic...
Standard adjuvant polychemotherapy for patients with breast cancer significantly improves their survival and is used for this patient group worldwide. In the beginning of this era, mainly CMF (cyclophosphamide, methotrexate and fluorouracil) was used but CMF is nowadays often replaced by...
Trastuzumab is a humanized monoclonal antibody developed to target the HER2 receptor which is over-expressed by some cancer cells, including 25 to 30% of breast cancers. Binding with high affinity to the extracellular domain of HER2, trastuzumab inhibits the proliferation of tumor cells that...
Although screening recommendations have been long established, more than 40 000 women died of breast cancer in the US in the year 2001. Risk factors for developing breast cancer have been identified, leading to the possibility of breast cancer prevention. Adjuvant tamoxifen for 5 years decreases...
Hypercalcemia of malignancy (HCM) is the most common cause of elevated serum calcium in hospitalized patients and is found with varying frequency in patients with various types of cancer. Calcium homeostasis is finely regulated with day-to-day variations of less than 2%, and the development of...
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