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The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the human response to chemicals, cosmetics and other consumer products are required for the safety...
Much worthy effort on the Three Rs is under way in the UK, but its promise of a reduction in laboratory animal use will only be credible and laudable when the number of procedures and animals are progressively and permanently reduced
Developmental toxicity testing could greatly benefit from the availability of an in vitro alternative model based on the use of animal embryos that have better human-like physiology than the currently-used alternative models. These current models are insufficient, as extrapolation of the results...
The decision to use laboratory animals rather than in vitro methods is frequently based on the financial costs involved, so the objective of our study was to compare the costs of performing the Mouse Inoculation Test (MIT) and Virus Isolation in Cell Culture (VICC) for use in rabies diagnosis in...
The stimulant effect of coffee on psychomotor performance was introduced as a potential alternative clinical pharmacology experiment for medical and pharmacy students
It is now 20 years since Russell and Burch last met to discuss, with others, the way forward for the Three Rs concept
The concerted research efforts undertaken in recent years have highlighted the potential of in vitro approaches, as part of an integrated testing strategy, to replace or reduce in vivo bioaccumulation testing in fish
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