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Reductions and refinements in the use of animals have steadily occurred over the last century. The need for improved health status has been a catalyst for much of this effort. This has also driven improvements in the housing and husbandry techniques required to maintain the health status of...
It has become increasingly difficult to perform animal experiments, because of issues related to the procurement of animals, and strict regulations and ethical issues related to their use. As a result, it is felt that the teaching of pharmacology should be more clinically oriented and that...
This study was set up to critically evaluate a commonly-used in vitro model of hepatocellular apoptotic cell death, in which freshly isolated hepatocytes, cultured in a monolayer configuration, are exposed to a combination of Fas ligand and cycloheximide for six hours. A set of well-acknowledged...
There has been increasing pressure from the public against animal experimentation for testing and research purposes. The Three Rs (replacement, reduction, and refinement) principle is thought to be a key foundation concept in optimising the welfare of animals used in experiments. This...
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