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The newly developed “chemical diversity approach” was used to determine whether or not it is likely that a panel of in vitro cell toxicity assays capable of predicting in vivo eye irritation could be assembled. The analyses, based upon available and validated structure–activity relationship...
A coherent structure-activity relationship (SAR) model was derived from data based on the toxicity of chemicals in cultured human HeLa cells. The ability to construct such a model indicates that toxicity is a function of a finite number of mechanisms. A comparison of the HeLa SAR model with...
A computer-based method is presented for the analysis and interpretation of structural formulae characterising chemical molecules. This method was developed to enable a computer to identify substructures of chemical molecules that are relevant in the context of specific toxicological questions....
Neuropeptides such as cholecystokinin (CCK) are subjected to a stepwise enzymic degradation (peptide processing) during axonal transport from the somata to the nerve terminals. This results in a continual change in the primary, secondary and tertiary structures of the peptide. Thus, an antibody...
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