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In order to evaluate in vitro the suitability of various prosthetic materials for endothelial seeding, human endothelial cells derived from the umbilical vein were placed in direct contact with a variety of polymers. As a control, endothelial cells were cultured in the absence of material. After...
Aldehyde dehydrogenases (ALDH) represent a major pathway for the enzymatic removal of many potentially toxic aldehydes. The purpose of this study was to examine the basal levels of ALDH in five hepatoma cell lines chosen as representatives of three different species (man, rat, mouse) and their...
The kinetochore-containing micronuclei induced in CHO cells by clastogenic and aneuploidogenic substances, such as mitomycin C (MMC) or colchicine, were distinguished by means of a technique based on the use of human CREST antikinetochore antibodies. Both substances induced their expected...
The CTFA Evaluation of Alternatives Program is a multi-year effort, organised by the CTFA Animal Welfare Task Force, designed to evaluate the performance of currently promising in vitro (alternative) methods to the Draize eye irritancy test. The sole criterion for inclusion of a particular test...
The aim of the present study was to investigate the relative cytotoxic effects of the detergents sodium dodecyl sulphate, Triton X-100, sodium oleate, stearyl etoxylate, sodium cholate and sodium taurocholate. Sodium dodecyl sulphate and stearyl etoxylate are used as dentifrice ingredients....
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