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SummaryAcrylamide, a well known neurotoxic compound, was used in a first evaluation of cultured mouse neuroblastoma cells as an alternative to animal models for neurotoxicological studies. Hence, the effects of acrylamide on the growth, size, morphology and leucine incorporation of three...
SummaryThe concentration of six surfactants required to block spontaneous contractions of rabbit isolated ileum by 50% (EC50) correlated well with in vivo eye irritancy (correlation coefficient -0.996) only when fresh ileum was tested at 35°C. Storage of ileum for 2 hr or 4 hr before testing did...
SummaryFungizone, the deoxycholate complex of Amphotericin B, is widely used in tissue culture media as a precaution against contamination. However, a number of reports indicate that the polyenes are toxic to certain mammalian cell lines at relatively low concentrations and can potentiate the...
SummaryThree related assay systems have been developed for the detection and evaluation of chemicals capable of inducing mitotic chromosome aneuploidy. These assays, which involve the use of yeast and mammalian cell cultures, have been evaluated for their potential utility by the study of the...
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