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Accurately refining biomacromolecules using a quantum‐chemical method is challenging because the cost of a quantum‐chemical calculation scales approximately as nm, where n is the number of atoms and m (≥3) is based on the quantum method of choice. This fundamental problem means that...
Cryogenic temperatures slow down secondary radiation damage during data collection from macromolecular crystals. In 1973, cooling at high pressure was identified as a method for cryopreserving crystals in their mother liquor [Thomanek et al. (1973). Acta Cryst. A29, 263–265]. Results from...
An addendum to the Introduction of Cole et al.[(2017), Acta Cryst. D73, 234–239] is made to recognize the work of Bricogne, Smart and others in the development of methods to make use of Cambridge Structural Database data in protein structure solution.
A review of Iron–Sulfur Clusters in Chemistry and Biology. Volume 1 edited by Tracey Rouault.
Biphenyl synthase and benzophenone synthase constitute an evolutionarily distinct clade of type III polyketide synthases (PKSs) that use benzoic acid‐derived substrates to produce defense metabolites in plants. The use of benzoyl‐CoA as an endogenous substrate is unusual for type III PKSs....
K‐Ras, a molecular switch that regulates cell growth, apoptosis and metabolism, is activated when it undergoes a conformation change upon binding GTP and is deactivated following the hydrolysis of GTP to GDP. Hydrolysis of GTP in water is accelerated by coordination to K‐Ras, where GTP adopts a...
The protein‐folding mechanism remains a major puzzle in life science. Purified soluble activation‐induced cytidine deaminase (AID) is one of the most difficult proteins to obtain. Starting from inclusion bodies containing a C‐terminally truncated version of AID (residues 1–153; AID153), an...
α‐Helical transmembrane proteins are a ubiquitous and important class of proteins, but present difficulties for crystallographic structure solution. Here, the effectiveness of the AMPLE molecular replacement pipeline in solving α‐helical transmembrane‐protein structures is assessed using a small...
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