Bladder Cancer Volume 1 Issue 1

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Journal Article

Editorial

2015 Bladder Cancer

doi:10.3233/BLC-159001 pmid:27376111

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Journal Article

Chemotherapy for Invasive Bladder Cancer: Five Simple Rules Learned Over 30 Years

Raghavan, Derek

2015 Bladder Cancer

doi:10.3233/BLC-150010 pmid:30561439

AbstractInvasive, clinically non-metastatic bladder cancer has a cure rate of only 50% , when all T stages are considered. The pattern of relapse is dominated by systemic spread, provided that optimal surgery is practiced. Occult metastases are thus most likely to be present at first...

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Immunotherapy and Radiation – A New Combined Treatment Approach for Bladder Cancer?

Buchwald, Zachary S.; Efstathiou, Jason A.

2015 Bladder Cancer

doi:10.3233/BLC-150014 pmid:30561443

AbstractRecently, immunotherapy with checkpoint inhibitors has been showing promise in clinical trials for stage IV bladder cancer. Herein, we review the literature regarding the role for radiation therapy, the role for immunotherapy, and the potential synergy of these treatments combined in...

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Clarification of Bladder Cancer Disease States Following Treatment of Patients with Intravesical BCG

2015 Bladder Cancer

doi:10.3233/BLC-159002 pmid:26807434

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Journal Article

High-throughput DNA Sequencing Identifies Novel CtIP (RBBP8) Variants in Muscle-invasive Bladder Cancer Patients

Jevons, Sarah J.; Green, Angela; Lunter, Gerton; Kartsonaki, Christiana; Buck, David;

2015 Bladder Cancer

doi:10.3233/BLC-150007 pmid:30561437

AbstractBackground: Germline mutations in DNA damage signalling and repair genes predispose individuals to cancer. Rare germline variants may also increase cancer risk and be predictive of outcomes following cancer treatments, but require high-throughput sequencing (HTS) for detection in large...

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The Prognostic Value of Cell Cycle Gene Expression Signatures in Muscle Invasive, High-Grade Bladder Cancer

Dancik, Garrett M.; Theodorescu, Dan

2015 Bladder Cancer

doi:10.3233/BLC-150012 pmid:30561442

AbstractBackground: Approximately half of patients with muscle invasive bladder cancer succumb to their disease. Previous work identified cell cycle related genes as a prognostic class of gene expression biomarkers in bladder cancer and found a specific 31-gene cell cycle proliferation (CCP)...

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Sequential Intravesical Gemcitabine and Docetaxel for the Salvage Treatment of Non-Muscle Invasive Bladder Cancer

Steinberg, Ryan L.; Thomas, Lewis J.; O’Donnell, Michael A.; Nepple, Kenneth G.

2015 Bladder Cancer

doi:10.3233/BLC-150008 pmid:30561441

AbstractBackground: Bacillus Calmette-Guerin (BCG) is the most effective intravesical therapy for non-muscle invasive bladder cancer (NMIBC), but patients can fail or supply shortages can develop. For BCG failures, radical cystectomy is recommended. However, in patients who desire bladder...

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Functional and Clinicopathologic Outcomes Using a Modified Vescica Ileale Padovana Technique

Flack, Chandra K.; Monn, M. Francesca; Kaimakliotis, Hristos Z.; Koch, Michael O.

2015 Bladder Cancer

doi:10.3233/BLC-140002 pmid:30561444

AbstractObjective: To evaluate the clinicopathologic and functional outcomes of a modified Vescica ileale Padovana (VIP) neobladder technique.Methods: Data for 160 patients at a single institution who underwent radical cystectomy and orthotopic VIP neobladder creation between 1998 and 2013 were...

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Therapeutic Effect on Bladder Cancer with a Conditionally Replicating Oncolytic Virus Derived from Type II Herpes Simplex Virus

Joo, Kwan Joong; Li, Hongtao; Zhang, Xiaoliu; Lerner, Seth P.

2015 Bladder Cancer

doi:10.3233/BLC-150013 pmid:30561438

AbstractPurpose: Despite recent improvements, resistance to traditional immunotherapy or chemotherapy is still common in patients with bladder cancer. We constructed an oncolytic virus from herpes simplex virus type II (HSV-2), which selectively targets tumor cells with an activated Ras signaling...

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Is Exam under Anesthesia Still Necessary for the Staging of Bladder Cancer in the Era of Modern Imaging?

Rozanski, Alexander T.; Benson, Cooper R.; McCoy, Jacob A.; Green, Charles; Grossman, H. Barton;

2015 Bladder Cancer

doi:10.3233/BLC-150006 pmid:30561436

AbstractBackground: The ability to accurately determine tumor stage in bladder cancer is critical because it impacts the management paradigm and overall prognosis. There is often discrepancy between clinical and pathologic staging. Historically, exam under anesthesia (EUA) has been recommended to...

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