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AbstractChemical-induced liver injury can be manifested in a number of ways, such as cholestasis, steatosis, fibrosis, and cancer. The mechanisms driving these toxicological processes have been well characterized and have been embedded in adverse outcome pathway frameworks in recent years. This...
AbstractThe current landscape of Adverse Outcome Pathways (AOPs) provides a means of organizing information relating to the adverse effects elicited following exposure to chemicals. As such, AOPs are an excellent driver for the development and application of in silico models for predictive...
AbstractThe Adverse Outcome Pathway (AOP) framework is increasingly used to integrate data based on traditional and emerging toxicity testing paradigms. As the number of AOP descriptions has increased, so has the need to define the AOP in computable terms. Herein, we present a comprehensive...
AbstractThere is a need to identify processes underlying development of chemically induced chronic disease in humans, preferably describing key events and their relationships in an adverse outcome pathway (AOP) analysis. Epigenetic modifications, and particularly DNA methylation effects, have...
AbstractGiven tremendous progress in biology, toxicology, and chemistry knowledge in recent decades, the time is right for serious consideration of options to move away from animal experimentation in chemical hazard and risk assessment. Individual alternative and animal-free assays as a...
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