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AbstractPrimary cultures of cryopreserved human hepatocytes have become the preferred model system to determine the potential of compounds to induce hepatic enzymes and transporters via nuclear receptor (NR) activation. Recently, it has been shown that cryopreserved hepatocytes retain viability,...
AbstractElectrical methods for monitoring cell toxicity are becoming increasingly popular because of their amenability for longer-term, continuous, and label-free monitoring. Microfabrication techniques are also opening the way for miniaturization of devices and integration with microphysiometer...
AbstractHigh-throughput, high-content imaging (HCI) assays for the key cellular events of neurodevelopment have been proposed to rapidly evaluate chemicals for developmental neurotoxicity. Thus, in vitro assays using neural cell cultures are being developed for key neurodevelopmental events,...
AbstractThe anti-inflammatory drug diclofenac (DCF) relieves postsurgery eye pain and can delay corneal wound healing. This study established a human ex vivo eye model and demonstrates the delay of wound healing by DCF. Human and rabbit response to topical DCF (0.1%) was evaluated after an...
AbstractPhenethylamines are ingredients in many dietary supplements aimed at supporting weight loss or maintaining heightened energy levels for productive workouts. This class of compounds affects the central nervous and cardiac systems, but there is evidence that 2-phenethylamine itself or its...
AbstractThere is a need for representative in vitro models to assess the effects of airborne particles on lung health. The objective of this study was to assess the cellular effects of cerium oxide (CeO2) particles exposed via an air–liquid interface in three relevant cell models in parallel....
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