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AbstractIt is evident from the drug development failures of the past 30 years that only through a better mechanistic understanding of specific drug-induced liver injury (DILI) will we improve our ability to predict clinical hepatotoxicity. Current in vitro models used for the prediction of DILI...
AbstractCurrent in vitro models of human skin lack appendages, which are an integral component of native skin and are necessary structures in reconstructed skin models for applications such as testing of pharmacological agents, basic discovery, and tissue engineering. We describe our development...
AbstractInhibition of hepatic efflux transporters (BSEP, MRP2) is one of the important mechanisms in drug-induced liver injury and in particular cholestasis. The inhibitory effect of compounds on these two hepatic transporters is commonly delineated using inverted membrane vesicles from Sf9...
AbstractFlatworms possess adult pluripotent stem cells whose dynamics can easily be experimentally assessed in vivo. This feature provides the unique opportunity to be used in a pharmacological context to test the safety of chemicals. The objective of this study was to develop and assess the...
AbstractDermal absorption data are required on agrochemical formulations to conduct risk assessments for subpopulations who may be exposed dermally to the formulation and/or its spray dilution, for example, operators/sprayers, bystanders (incidental and residential), and re-entry workers. In the...
AbstractDuring the past three decades, great progress has been achieved in the development of in vitro reconstructed human epidermal (RhE) tissue models. This technology is now available via various manufacturers of commercially available tissue models, and has provided opportunities for...
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