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With current therapy more than 80% of children with acute lymphoblastic leukaemia (ALL) can be cured in industrialized countries. However, ALL is still amongst the leading causes of death from disease in children aged 1–15 years. Of note, antileukaemic medications can cause significant adverse...
The report summarizes several lectures that proved particularly notable for paediatric haematologists at the ASH meeting 2008. Neal S. Young (NIH, Bethesda, U.S.A.) illustrated his findings about the frequent impact of telomere shortening caused by mutations in the telomerase complex in the...
In this review we describe general therapeutic options for adult patients with acute lymphoblastic leukaemia and focus on specific new treatment strategies. Current novel approaches include monoclonal antibodies against leukaemic-associated antigens, new formulations of existing chemotherapeutic...
Myeloproliferative diseases (MPD) are characterized by the clonal expansion of mature myeloid cells. A reciprocal translocation between chromosome 9 and 22 is responsible for chronic myeloid leukaemia but not for the so-called Philadelphia Chromosome/BCR-ABL-negative MPDs. With the detection of...
Although the outcome of patients with non-Hodgkin lymphoma (NHL) has, in general, improved significantly over years, treatment failure due to drug resistance remains a problem. Recently, the focus of drug development has shifted from conventional cytotoxic drugs to agents directed against...
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