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Cellular and Molecular Immunology

Subject Areas: Immunology
Publisher: Nature Publishing Group UK - Springer Journals
ISSN: 1672-7681
SJR: 93

LitStream

Journal Article

Targeting macrophage metabolism to enhance tumor immunotherapy

Liu, Jing; Ma, Zhibo; Jia, Wenlong; Lan, Peixiang

2024 Cellular and Molecular Immunology

doi:10.1038/s41423-024-01149-7
LitStream

Journal Article

Neuropilin-1high monocytes protect against neonatal inflammation

Zheng, Xiaoqing; Lei, Wen; Zhang, Yongmei; Jin, Han; Han, Cha; Wu, Fan; Jia, Chonghong; Zeng, Ruihong; Chen, Zhanghua; Zhang, Yuxia; Wang, Haitao; Liu, Qiang; Yao, Zhi; Yu, Ying; Zhou, Jie

2024 Cellular and Molecular Immunology

doi:10.1038/s41423-024-01157-7

Neonates are susceptible to inflammatory disorders such as necrotizing enterocolitis (NEC) due to their immature immune system. The timely appearance of regulatory immune cells in early life contributes to the control of inflammation in neonates, yet the underlying mechanisms of which remain...
LitStream

Journal Article

Bypassing PELO-mediated ATPase activation of the NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases

Wu, Xiurong; Yang, Zhang-Hua; Zheng, Yue; Wu, Jianfeng; Han, Jiahuai

2024 Cellular and Molecular Immunology

doi:10.1038/s41423-024-01162-w
LitStream

Journal Article

GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14

Liu, Qianjin; Jiao, Lijin; Ye, Mao-Sen; Ma, Zhiyu; Yu, Jinsong; Su, Ling-Yan; Zou, Wei-Yin; Yang, Lu-Xiu; Chen, Chang; Yao, Yong-Gang

2024 Cellular and Molecular Immunology

doi:10.1038/s41423-024-01155-9 pmid:38570588

Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous diseases. However, the precise molecular mechanisms that modulate the transcriptional regulation of NLRP3 remain largely unknown. In this study, we demonstrated that S-nitrosoglutathione reductase...
Open Access

Journal Article

Synthetic biology approaches for improving the specificity and efficacy of cancer immunotherapy

Zhu, Bo; Yin, Hang; Zhang, Di; Zhang, Meiling; Chao, Xiaojuan; Scimeca, Luca; Wu, Ming-Ru

2024 Cellular and Molecular Immunology

doi:10.1038/s41423-024-01153-x pmid:38605087

Immunotherapy has shown robust efficacy in treating a broad spectrum of hematological and solid cancers. Despite the transformative impact of immunotherapy on cancer treatment, several outstanding challenges remain. These challenges include on-target off-tumor toxicity, systemic toxicity, and the...
Open Access

Journal Article

Cellular metabolism regulates the differentiation and function of T-cell subsets

Ma, Sicong; Ming, Yanan; Wu, Jingxia; Cui, Guoliang

2024 Cellular and Molecular Immunology

doi:10.1038/s41423-024-01148-8 pmid:38565887

T cells are an important component of adaptive immunity and protect the host from infectious diseases and cancers. However, uncontrolled T cell immunity may cause autoimmune disorders. In both situations, antigen-specific T cells undergo clonal expansion upon the engagement and activation of...

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